{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:59:20Z","timestamp":1753739960746},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Coeliac disease (CD<\/jats:styled-content>) has been linked to an increased risk of ischaemic heart disease (IHD<\/jats:styled-content>). We examined the risk of IHD<\/jats:styled-content> in first\u2010degree relatives and spouses to coeliac patients to ascertain the genetic contribution to IHD<\/jats:styled-content> excess risk.<\/jats:p><\/jats:sec>Study design and setting<\/jats:title>Coeliac disease was defined as having a biopsy\u2010verified villous atrophy (Marsh grade 3) in 1969\u20132008 (n<\/jats:italic>\u00a0=\u00a029\u00a0096). Coeliac patients were matched to 144\u00a0522 controls. Through Swedish registers, we identified all first\u2010degree relatives and spouses to coeliac patients and their controls, in total 87\u00a0622 unique coeliac relatives and 432\u00a0655 unique control relatives. Our main outcome measure was IHD<\/jats:styled-content> defined according to relevant international classification of disease codes in the Swedish Inpatient Registry or in the Cause of Death Registry. Hazard ratios (HR<\/jats:styled-content>) and confidence intervals (CI<\/jats:styled-content>) were estimated through Cox regression adjusted for sex, age\u2010group and calendar year at study entry of the relative.<\/jats:p><\/jats:sec>Result<\/jats:title>During a median follow\u2010up of 10\u00b78\u00a0years, 2880 coeliac relatives and 13\u00a0817 control relatives experienced IHD<\/jats:styled-content>. First\u2010degree relatives of coeliac patients were at increased risk of IHD<\/jats:styled-content> (HR<\/jats:styled-content>\u00a0=\u00a01\u00b705; 95% CI<\/jats:styled-content>\u00a0=\u00a01\u00b700\u20131\u00b709, P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b704), while spouses were at no increased risk (HR<\/jats:styled-content>\u00a0=\u00a00\u00b799; 95% CI<\/jats:styled-content>\u00a0=\u00a00\u00b787\u20131\u00b712). The excess risk of IHD<\/jats:styled-content> in coeliac first\u2010degree relatives aged 40\u201359\u00a0years was 70\/100\u00a0000 person\u2010years.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>First\u2010degree relatives to coeliac patients seem to be at an increased risk of IHD<\/jats:styled-content> but the excess risk is so small that it has little clinical relevance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12242","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T14:30:17Z","timestamp":1391005817000},"page":"359-364","source":"Crossref","is-referenced-by-count":6,"title":["Ischaemic heart disease in first\u2010degree relatives to coeliac patients"],"prefix":"10.1111","volume":"44","author":[{"given":"Louise","family":"Emilsson","sequence":"first","affiliation":[{"name":"Primary care research unit V\u00e5rdcentralen V\u00e4rmlands Nys\u00e4ter V\u00e4rmland County Sweden"},{"name":"Department of Medicine \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.03.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.965624"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03594.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02008.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12271"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-19"},{"key":"e_1_2_11_9_1","volume-title":"The Total Population Register of Statistics Sweden. New Possibilities and Better Quality","author":"Johannesson I","year":"2002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1320"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-423-0_10"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.3.495"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.028027"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-029-8_26"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.543"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.961243"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.04.008"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2008.07.010"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.60"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03625.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.960"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509297248"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520903132013"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.018820"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:32:51Z","timestamp":1696282371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/eci.12242"],"URL":"https:\/\/doi.org\/10.1111\/eci.12242","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]}}}