{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:10:31Z","timestamp":1788999031506,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is hypothesised that the autonomic nervous system responds differently to various stressors in patients with chronic fatigue syndrome (<jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>) compared with healthy controls. The goal is to systematically review the scientific literature addressing the functioning of the autonomic nervous system in patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>All studies that were identified through electronic databases (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>eb of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cience) were screened for eligibility based on the selection criteria and assessed (two independent raters) for methodological quality using a methodological checklist for case\u2013control studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven case\u2013control studies were included. The methodological quality varied between 50% and 71\u00b74%. Some studies showed different responses to head\u2010up tilt and other autonomous testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although comparison between the included case\u2013control studies was difficult, we can conclude that there are differences in autonomous response between patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content> and healthy controls. The heart rate dynamic response during the head\u2010up tilt test differs between patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content> and healthy controls, supporting the increased prevalence of postural orthostatic tachycardia syndrome. The autonomic response can be useful for the diagnosis of <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12256","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T05:23:05Z","timestamp":1394169785000},"page":"516-526","source":"Crossref","is-referenced-by-count":81,"title":["Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review"],"prefix":"10.1111","volume":"44","author":[{"given":"Deborah","family":"Van Cauwenbergh","sequence":"first","affiliation":[{"name":"Pain in Motion Research Group Departments of Human Physiology and Rehabilitation Sciences Faculty of Physical Education &amp; Physiotherapy Vrije Universiteit Brussel Brussel Belgium"},{"name":"Pain in Motion Research Group Faculty of Medicine and Health Sciences University of Antwerp Antwerp 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