{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:54:28Z","timestamp":1792356868962,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Vitamin D<\/jats:styled-content> (25\u2010OH<\/jats:styled-content> D3) deficiency represents a rising social and economic problem in Western countries. Vitamin D<\/jats:styled-content> has been recently reported to modulate inflammatory processes, endothelium and smooth muscle cell proliferation and even platelet function, thus potentially modulating atherothrombosis. Great interest has been addressed on its impact on cardiovascular outcome, with contrasting results. The aim of current study was to evaluate the relationship between 25\u2010OH<\/jats:styled-content> D3 and the extent of coronary artery disease (CAD) in a consecutive cohort of patients undergoing coronary angiography.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Patients undergoing elective coronary angiography were included in a cross\u2010sectional study. Fasting samples were collected for 25\u2010OH<\/jats:styled-content> D3 levels assessment. Significant CAD<\/jats:styled-content> was defined as at least 1 vessel stenosis >\u00a050%, while severe CAD<\/jats:styled-content> as left main and\/or trivessel disease, as evaluated by quantitative coronary angiography.<\/jats:p><\/jats:sec>Results<\/jats:title>Hypovitaminosis D<\/jats:styled-content> was observed in 70\u00b74% of 1484 patients. Patients were divided according to vitamin D<\/jats:styled-content> tertiles (<\u00a09\u00b76; 9\u00b76\u201318\u00b74; \u2265\u00a018\u00b74). Lower vitamin D<\/jats:styled-content> levels were associated with age, female gender (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00\u00b7001), renal failure (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b705), active smoking (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7001), acute coronary syndrome at presentation (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00\u00b7001), therapy with calcium antagonists (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b702) and diuretics (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00\u00b7001), less beta\u2010blockers (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b702) and statins (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7001) use. Vitamin D was directly related to haemoglobin (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00\u00b7001) and inversely with platelet count (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7002), total and low\u2010density\u2010lipoprotein cholesterol (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7002 and P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00\u00b7001) and triglycerides (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b701). Vitamin D<\/jats:styled-content> did not influence angiographic features of coronary lesions, but was associated with higher prevalence of left main or right CAD (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b703). Vitamin D deficiency was significantly associated with higher prevalence of CAD<\/jats:styled-content> (adjusted OR<\/jats:styled-content> [95%CI<\/jats:styled-content>]\u00a0=\u00a01\u00b732[1\u00b71\u20131\u00b76], P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7004) and severe CAD<\/jats:styled-content> (adjusted OR<\/jats:styled-content> [95%CI<\/jats:styled-content>]\u00a0=\u00a01\u00b718[1\u20131\u00b739], P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b705).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Hypovitaminosis D<\/jats:styled-content> was observed in the vast majority of patients undergoing coronary angiography. Vitamin D<\/jats:styled-content> deficiency is significantly associated with the prevalence and extent of CAD<\/jats:styled-content>, especially for patients with values <\u00a010\u00a0ng\/mL. Therefore, future large studies are needed to evaluate whether vitamin D<\/jats:styled-content> supplementation may prevent CAD<\/jats:styled-content> and its progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12281","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T15:44:49Z","timestamp":1400082289000},"page":"634-642","source":"Crossref","is-referenced-by-count":82,"title":["Vitamin D<\/scp> deficiency is independently associated with the extent of coronary artery disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Monica","family":"Verdoia","sequence":"first","affiliation":[{"name":"Department of Cardiology Ospedale \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University 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Piedmont University Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Galasso","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale \u201cMaggiore della Carit\u00e0\u201d Eastern Piedmont University Novara 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