{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:18:49Z","timestamp":1783487929360,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The prevalence of primary aldosteronism (PA<\/jats:styled-content>) in hypertensive patients varies according to diagnostic testing and ascertained normal cut\u2010offs. The aim of this case\u2013control study was to confirm the high prevalence of PA<\/jats:styled-content> in a large hypertensive population and evaluate the antihypertensive effect of mineralocorticoid receptor antagonists (MRA<\/jats:styled-content>) treatment.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>We investigated 327 hypertensive and 90 matched normotensive subjects with normal adrenal imaging. Serum aldosterone (ALD<\/jats:styled-content>), active renin (REN<\/jats:styled-content>) levels and aldosterone\/active renin (ALD\/REN<\/jats:styled-content>) ratio were measured before and after a combined sodium chloride, fludrocortisone and dexamethasone suppression test (FDST<\/jats:styled-content>). Post\u2010FDST<\/jats:styled-content> values were compared to cut\u2010offs obtained from controls (post\u2010FDST ALD<\/jats:styled-content> 2\u00b796\u00a0ng\/dL and post\u2010FDST ALD\/REN<\/jats:styled-content> 0\u00b793\u00a0ng\/dL\/\u03bcU\/mL). PA<\/jats:styled-content> patients received MRA<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>By applying the combination of post\u2010FDST ALD<\/jats:styled-content> levels and ALD\/REN<\/jats:styled-content> ratio, 28\u00b77% of the hypertensive patients had PA<\/jats:styled-content>. There was a positive, albeit weak, correlation between systolic (SBP<\/jats:styled-content>) and diastolic blood pressure (DBP<\/jats:styled-content>) and ALD<\/jats:styled-content> levels and\/or ALD\/REN<\/jats:styled-content> ratio after the FDST<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b70001). SBP was associated with a post\u2010FDST ALD<\/jats:styled-content> of 3\u00b724\u00a0ng\/dL and ALD\/REN ratio of 0\u00b790\u00a0ng\/dL\/\u03bcU\/mL, whereas post\u2010FDST ALD<\/jats:styled-content> had an inverse association at serum K+ values of less than 3\u00b79\u00a0mEq\/L. MRA<\/jats:styled-content> treatment in 69 PA<\/jats:styled-content> patients, resulted in a significant reduction in the maximum SBP<\/jats:styled-content> and DBP<\/jats:styled-content> values (28\u00a0\u00b1\u00a015 and 14\u00a0\u00b1\u00a07\u00a0mmHg, respectively, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b70001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Using the FDST<\/jats:styled-content>, an increased prevalence of PA<\/jats:styled-content> in hypertensives was observed. \u0391 significant blood pressure lowering effect was obtained with MRA<\/jats:styled-content> treatment, implying that these agents may be beneficial in a significant number of hypertensive patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12286","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T08:03:38Z","timestamp":1402128218000},"page":"697-706","source":"Crossref","is-referenced-by-count":21,"title":["Primary aldosteronism in hypertensive patients: clinical implications and target therapy"],"prefix":"10.1111","volume":"44","author":[{"given":"Labrini","family":"Papanastasiou","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Markou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Pappa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki","family":"Gouli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsounas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Fountoulakis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kounadi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Tsiama","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Center \u2018G Gennimatas\u2019 General Hospital Athens 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