{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:02:08Z","timestamp":1778547728986,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Infection is often accompanied by lipid profile alterations. The aim of this study was to evaluate the lipid profile changes in patients with visceral leishmaniasis (VL<\/jats:styled-content>).<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>We included 15 patients [10 men, aged 50 (24\u201382) years old] with VL<\/jats:styled-content> and 15 age\u2010 and sex\u2010matched controls. The parameters estimated at diagnosis and 4\u00a0months after VL<\/jats:styled-content> resolution were total cholesterol (TC<\/jats:styled-content>), high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C<\/jats:styled-content>), triglycerides (TG<\/jats:styled-content>s), low\u2010density lipoprotein cholesterol (LDL<\/jats:styled-content>\u2010C<\/jats:styled-content>), apolipoproteins (apo) A<\/jats:styled-content>\u2010\u0399<\/jats:styled-content>, B<\/jats:styled-content>, E<\/jats:styled-content>, C<\/jats:styled-content>\u2010II<\/jats:styled-content>, C<\/jats:styled-content>\u2010III<\/jats:styled-content>, lipoprotein (a) [L<\/jats:styled-content>p(a)], activities of lipoprotein\u2010associated phospholipase A<\/jats:styled-content>2<\/jats:sub> (L<\/jats:styled-content>p\u2010PLA<\/jats:styled-content>2<\/jats:sub>), HDL<\/jats:styled-content>\u2010L<\/jats:styled-content>p\u2010PLA<\/jats:styled-content>2<\/jats:sub>, PON<\/jats:styled-content>1 (paraoxonase 1) and cholesterol ester transfer protein (CETP<\/jats:styled-content>), cytokines (interleukins 1\u03b2 and 6 and tumour necrosis factor \u03b1), as well as LDL<\/jats:styled-content> subfraction profile.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with VL<\/jats:styled-content> at diagnosis had lower levels of TC<\/jats:styled-content>, LDL<\/jats:styled-content>\u2010C, apo\u0392<\/jats:styled-content> and L<\/jats:styled-content>p(a), and higher TG<\/jats:styled-content> and apoE<\/jats:styled-content> concentrations compared with 4\u00a0months after VL<\/jats:styled-content> resolution. The activities of L<\/jats:styled-content>p\u2010PLA<\/jats:styled-content>2<\/jats:sub>, HDL<\/jats:styled-content>\u2010L<\/jats:styled-content>p\u2010PLA<\/jats:styled-content>2<\/jats:sub> and \u03a1\u039f\u039d<\/jats:styled-content>1 were reduced at diagnosis compared with post\u2010treatment values. VL<\/jats:styled-content> patients had decreased levels of both large and sdLDL<\/jats:styled-content>\u2010C<\/jats:styled-content> at diagnosis; no effect on mean LDL<\/jats:styled-content> particle size was observed. Patients with VL<\/jats:styled-content> at diagnosis had decreased HDL<\/jats:styled-content>\u2010C<\/jats:styled-content> and apoA<\/jats:styled-content>\u2010I<\/jats:styled-content> concentrations; these increased 4\u00a0months after VL<\/jats:styled-content> resolution, but remained lower compared with controls. The activities of HDL<\/jats:styled-content>\u2010L<\/jats:styled-content>p\u2010PLA<\/jats:styled-content>2<\/jats:sub> and PON<\/jats:styled-content>1 remained lower in patients after VL<\/jats:styled-content> resolution compared with controls.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with VL<\/jats:styled-content> exhibit increased TG<\/jats:styled-content> levels and decreased cholesterol subclasses at diagnosis. HDL<\/jats:styled-content>\u2010C<\/jats:styled-content>, apoA<\/jats:styled-content>\u2010I<\/jats:styled-content> and associated enzymes remain lower 4\u00a0months after VL<\/jats:styled-content> resolution compared with controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12288","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T17:27:13Z","timestamp":1402507633000},"page":"719-727","source":"Crossref","is-referenced-by-count":19,"title":["Visceral leishmaniasis is associated with marked changes in serum lipid profile"],"prefix":"10.1111","volume":"44","author":[{"given":"Evangelos N.","family":"Liberopoulos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Medical School University of Ioannina Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotini","family":"Apostolou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical School University of Ioannina 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