{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:22:07Z","timestamp":1773260527036,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In most previous studies investigating efficacy of renal denervation (<jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>), patients with multiple renal arteries are generally excluded from treatment. This study was designed to determine the prevalence of multiple renal arteries in patients referred for <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>, to propose a classification for anatomical eligibility and to investigate the relation between the presence of multiple arteries and blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>)\u2010lowering effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients referred for <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> who underwent noninvasive imaging of the renal arteries before treatment were included in present analysis. Eligible patients were treated. Renal function and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were evaluated 6\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hundred and twenty\u2010six patients referred for <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> were included in present analysis. Thirty\u2010four per cent had multiple arteries. Sixty\u2010nine patients underwent <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>. Office <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> significantly reduced from 195 (\u00b1\u00a026)\/ 106 (\u00b1\u00a014) mmHg to 165 (\u00b1\u00a024)\/ 95 (\u00b1\u00a014) mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> reduction in patients with multiple arteries which were all treated was comparable to patients with solitary arteries. However, patients with multiple which were not all treated showed a trend towards a less pronounced effect of <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> (\u03b2: 11\u00b76, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b711). The proposed classification appeared useful by identifying eligible anatomy. Renal function at 6\u00a0months did not differ from baseline in all subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on our results and the high prevalence of multiple arteries, it seems reasonable not to exclude patients with multiple renal arteries from <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>. Current analysis suggests that <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> reduction may be less pronounced in patients with multiple renal arteries of whom not all arteries were treated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12289","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T22:59:18Z","timestamp":1402959558000},"page":"728-735","source":"Crossref","is-referenced-by-count":13,"title":["Renal denervation in multiple renal arteries"],"prefix":"10.1111","volume":"44","author":[{"given":"Willemien L.","family":"Verloop","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva E.","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilko","family":"Spiering","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Blankestijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel L.","family":"Bots","sequence":"additional","affiliation":[{"name":"The Julius Center for Health Sciences and Primary Care University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert\u2010jan","family":"Vonken","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Voskuil","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht the 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