{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:48:50Z","timestamp":1771303730116,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The appropriate timing for surgery in severe asymptomatic primary mitral regurgitation (MR) remains controversial. It has been shown that late gadolinium enhancement on cardiovascular magnetic resonance (LGE CMR), which may identify myocardial fibrosis, is associated with a worse outcome in various cardiomyopathies. We sought to investigate the prevalence and significance of delayed enhancement in primary MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included 41 patients with at least moderate primary MR and without overt signs of left ventricular (LV) dysfunction. Patients with evidence of coronary artery disease, arrhythmias or significant concomitant valvular disease were excluded. All patients were scheduled for transthoracic echocardiography and LGE CMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 39 patients had interpretable LGE CMR images. Among them, 12 (31%) had late contrast uptake of the LV wall. LGE CMR showed an infarct pattern in three patients, a pattern of mid\u2010wall fibrosis in seven patients and two patients had a combined pattern. Patients with delayed enhancement on CMR had significant higher LV diameters (LV end\u2010systolic diameter 39\u00a0\u00b1\u00a04 vs. 34\u00a0\u00b1\u00a05\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002; LV end\u2010diastolic diameter 57\u00a0\u00b1\u00a05 vs. 50\u00a0\u00b1\u00a05\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). There was a trend towards a higher indexed left atrial volume (55\u00a0\u00b1\u00a021 vs. 44\u00a0\u00b1\u00a013\u00a0mL\/m\u00b2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b706). By contrast, there was no significant association between myocardial contrast uptake and age, LV ejection fraction and MR severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left ventricular remodelling seems to be associated with the presence of delayed enhancement on CMR in primary MR. Further data are needed to determine whether LGE CMR can predict a less favourable outcome or could improve risk stratification in asymptomatic primary MR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12306","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T16:18:43Z","timestamp":1406305123000},"page":"840-847","source":"Crossref","is-referenced-by-count":27,"title":["Late gadolinium enhancement CMR in primary mitral regurgitation"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-4732","authenticated-orcid":false,"given":"Caroline M.","family":"Van De Heyning","sequence":"first","affiliation":[{"name":"GIGA Cardiovascular Sciences Heart Valve Clinic Department of Cardiology, CHU Sart Tilman University of Li\u00e8ge Hospital Li\u00e8ge Belgium"},{"name":"Department of Cardiology University of Antwerp Hospital Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Magne","sequence":"additional","affiliation":[{"name":"GIGA Cardiovascular Sciences Heart Valve Clinic Department of Cardiology, CHU Sart Tilman University of Li\u00e8ge Hospital Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc A.","family":"Pi\u00e9rard","sequence":"additional","affiliation":[{"name":"GIGA Cardiovascular Sciences Heart Valve Clinic Department of Cardiology, CHU Sart Tilman University of Li\u00e8ge Hospital Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Julien","family":"Bruy\u00e8re","sequence":"additional","affiliation":[{"name":"Thoracic and Cardiovascular Imaging Department of Radiology, CHU Sart Tilman University of Li\u00e8ge Hospital Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Davin","sequence":"additional","affiliation":[{"name":"GIGA Cardiovascular Sciences Heart Valve Clinic Department of Cardiology, CHU Sart Tilman University of Li\u00e8ge Hospital Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"De Maeyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Antwerp Hospital Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard P.","family":"Paelinck","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Antwerp Hospital Edegem Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan J.","family":"Vrints","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Antwerp Hospital Edegem 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