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The periodontal biofilm associated with periodontitis comprises of gram\u2010positive and gram\u2010negative bacteria, instrumental for the initiation and progression of periodontitis. Evidence\u2010based literature has identified the nature of periodontal infection as a possible causative condition in the inducement of \u2018low\u2010grade systemic inflammation and infection\u2019. The periodontal pathogens exert systemic effects via the haematogenous route.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present review provides an insight into the pathophysiology of the endothelial dysfunction with reference to periodontal infection and highlights the association between periodontitis and endothelial dysfunction. Various studies addressing the implication of periodontitis on endothelial dysfunction will be described, with a focus of periodontal treatment on improvement of endothelial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Studies examining the effects of periodontitis on vascular endothelial function were segregated. Studies conducted on both animal and human models were identified using <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> database search with key search terms such as \u2018Periodontitis\u2019, \u2018vascular endothelium\u2019, \u2018endothelial dysfunction\u2019, \u2018periodontal bacteria\u2019 and \u2018periodontal therapy\u2019. Systematic reviews and meta\u2010analysis were also screened. Only studies published in English language were considered. The review has been prepared by screening <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> database from 1989 to 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>Chronic periodontitis results in altered vascular response, increased expression of pro\u2010inflammatory cytokines and adhesion molecules inducing vascular endothelial dysfunction. Periodontal therapy may ameliorate the perturbed vascular endothelial function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12322","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T14:06:06Z","timestamp":1407420366000},"page":"1000-1009","source":"Crossref","is-referenced-by-count":92,"title":["The implication of periodontitis in vascular endothelial dysfunction"],"prefix":"10.1111","volume":"44","author":[{"given":"Abhijit N.","family":"Gurav","sequence":"first","affiliation":[{"name":"Department of Periodontics Tatyasaheb Kore Dental College &amp; Research Centre Kolhapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01673.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.779"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009321"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00107.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601105010110"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01436.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080183"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701854702"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829760"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2008.02.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(10)52004-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.11.002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2000.109000"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.07.017"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000132474.50966.DA"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338150"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401004010302"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786898761"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.093245"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.587893"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.08.262"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2106"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01249.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01169.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.08.016"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.108886"},{"key":"e_1_2_11_32_1","first-page":"2135","article-title":"Is C\u2010reactive protein an innocent bystander or proatherogenic culprit? 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