{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:44:31Z","timestamp":1791305071830,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Coupled arterial and left ventricular properties are poorly documented in acute heart failure. The aim of this prospective noninvasive study was to document early changes in ventricular\u2013arterial coupling in patients with acutely decompensated <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We studied 19 patients hospitalized for ADHF (age 62\u00a0\u00b1\u00a015\u00a0years, NYHA class 3 or 4). Patients with shock and sustained arrhythmias were excluded. All the patients received intravenous loop diuretics, and none received intravenous vasodilators or inotropes. Ongoing chronic treatments were maintained. Echocardiography and radial artery tonometry were performed simultaneously on admission and after clinical improvement (day 4\u00a0\u00b1\u00a01 after admission). Classical echocardiographic parameters were measured, including stroke volume (SV). End\u2010systolic pressure (Pes) was derived from reconstructed central aortic pressure, and arterial elastance (Ea) was calculated as Ea\u00a0=\u00a0Pes\/SV. End\u2010systolic LV elastance (Ees) was calculated with the single\u2010beat method. Ventricular\u2013arterial coupling was quantified as the Ea\/Ees ratio. Following IV diuretic therapy, mean weight loss was 5\u00a0\u00b1\u00a02\u00a0kg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and BNP fell from 1813 (median) (IQR\u00a0=\u00a01284\u20132342) to 694 (334\u20131053)\u00a0pg\/mL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). Ea fell by 29%, from 2\u00b746 (2\u00b705\u20132\u00b786) to 1\u00b778 (1\u00b755\u20132\u00b700) mmHg\/mL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), while Ees remained unchanged (1\u00b728 (1\u00b705\u20131\u00b752) to 1\u00b713 (0\u00b792\u20131\u00b734) mmHg\/mL). The Ea\/Ees ratio therefore fell, from 2\u00b713 (1\u00b770\u20132\u00b756) to 1\u00b781 (1\u00b756\u20132\u00b708) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b702).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An early improvement in ventricular\u2013arterial coupling was observed after diuretic\u2010related decongestive therapy in <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> patients and was related to a decrease in effective arterial elastance rather than to change in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> contractility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12332","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T20:00:59Z","timestamp":1409860859000},"page":"982-988","source":"Crossref","is-referenced-by-count":13,"title":["Changes in ventricular\u2013arterial coupling during decongestive therapy in acute heart failure"],"prefix":"10.1111","volume":"44","author":[{"given":"Emmanuelle","family":"Berthelot","sequence":"first","affiliation":[{"name":"Department of cardiology Bicetre Hospital, AP\u2010HP Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bihry","sequence":"additional","affiliation":[{"name":"Department of cardiology Lariboisiere Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophelie","family":"Brault\u2010Melin","sequence":"additional","affiliation":[{"name":"Department of cardiology Lariboisiere Hospital, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Assayag","sequence":"additional","affiliation":[{"name":"Department of cardiology Bicetre Hospital, AP\u2010HP Le Kremlin\u2010Bic\u00eatre France"},{"name":"Paris\u2010Sud University Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Cohen\u2010Solal","sequence":"additional","affiliation":[{"name":"Department of cardiology Lariboisiere Hospital, AP\u2010HP Paris France"},{"name":"INSERM UMRS 942 Paris France"},{"name":"Paris\u2010Diderot University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Chemla","sequence":"additional","affiliation":[{"name":"Paris\u2010Sud University Le Kremlin\u2010Bic\u00eatre France"},{"name":"Department of Physiology Bicetre Hospital, AP\u2010HP Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Logeart","sequence":"additional","affiliation":[{"name":"Department of cardiology Lariboisiere Hospital, AP\u2010HP Paris France"},{"name":"INSERM UMRS 942 Paris France"},{"name":"Paris\u2010Diderot University Paris 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