{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:55:35Z","timestamp":1773111335099,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council Taiwan","doi-asserted-by":"publisher","award":["102-2811-B-010 -057"],"award-info":[{"award-number":["102-2811-B-010 -057"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) experience repetitive cessation of breathing during sleep, leading to intermittent hypoxaemia, excessive oxidative stress and systemic inflammation. These insults may damage the vasculature and provoke the corresponding repair response, such as stem cell mobilization to peripheral blood. This study aimed to investigate nocturnal mobilization of stem cells in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> and thirteen healthy controls were enrolled. Polysomnography was performed, and severity of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> was defined by apnoea\u2013hypopnoea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>). Peripheral venous blood was drawn after and before sleep for measurement of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cell and <jats:styled-content style=\"fixed-case\">SDF<\/jats:styled-content>\u20101\u03b1 level. Stem cell mobilization was gauged by ratios of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ level in the morning to that at night or by their difference. Correlation analysis was performed to identify factors related to stem cell mobilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, the nocturnal ratios and difference of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cell levels were larger in patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> (ratios: 1\u00b7141 vs. 0\u00b7896, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7036; difference: 340 vs. \u2212166\/cc blood, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7036), suggestive of stem cell mobilization. The mobilization ratios were related to <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), SpO2 nadir, oxygen desaturation index and time sustaining hypoxaemia. After adjusting age, gender and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AHI<\/jats:styled-content> (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7357, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7016) and hypoxaemia\u2010related parameter remained significant. Paired nocturnal differences in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ cell count (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7009) and <jats:styled-content style=\"fixed-case\">SDF<\/jats:styled-content>\u20101\u03b1 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001) were also significant in patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>, but not in controls. After <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy for 6\u00a0months, the elevated mobilization ratios in patients with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> tended to decline (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7059).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34+ stem cell mobilization during sleep was observed in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12353","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T06:04:49Z","timestamp":1413871489000},"page":"1189-1196","source":"Crossref","is-referenced-by-count":3,"title":["Nocturnal stem cell mobilization in patients with obstructive sleep apnoea: a pilot study"],"prefix":"10.1111","volume":"44","author":[{"given":"Kun\u2010Ta","family":"Chou","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Thoracic Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Shui","family":"Hsu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Thoracic Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Chuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diahn\u2010Warng","family":"Perng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Tong","family":"Hsu","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Chieh","family":"Hung","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Stem Cell Laboratory Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Orthopedics Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Biomedical Sciences Academia Sinica Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.780"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61622-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.02.010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.4.447"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.11.1439"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-91"},{"key":"e_1_2_6_8_1","first-page":"117","article-title":"Obstructive apneas induce early release of mesenchymal stem cells into circulating blood","volume":"32","author":"Carreras A","year":"2009","journal-title":"Sleep"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109643"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-008-9073-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-11-200606060-00004"},{"key":"e_1_2_6_12_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber C","year":"2007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0468"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1831"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0164"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.02.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1845OC"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06685"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728221003769887"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2010.12.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn081"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2010.1086"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12353","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:03:49Z","timestamp":1696363429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/eci.12353"],"URL":"https:\/\/doi.org\/10.1111\/eci.12353","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}