{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:14Z","timestamp":1790470154692,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F4704-B20, F4705-B20"],"award-info":[{"award-number":["F4704-B20, F4705-B20"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concept of leukaemic stem cells (<jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>s) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> eradication in these patients. Some of the newly discovered <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> markers seem to be expressed in a disease\u2010specific manner and may thus serve as major research tools and diagnostic parameters. A useful <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> marker in chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) appears to be <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>26, also known as dipeptidylpeptidase <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>26 is largely restricted to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34<jats:sup>+<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38<jats:sup>\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>, but is not found on <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>s in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BCR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<jats:sub>p210<\/jats:sub>+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>26 usually is not expressed on normal bone marrow (BM) stem cells. Functionally, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>26 is a cytokine\u2010targeting surface enzyme that may facilitate the mobilization of <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>s from the BM niche. In this article, we review our current knowledge about the biology and function of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>26 on <jats:styled-content style=\"fixed-case\">CML LSC<\/jats:styled-content>s and discuss the diagnostic potential of this new <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> marker in clinical haematology.<\/jats:p>","DOI":"10.1111\/eci.12368","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T06:44:28Z","timestamp":1415169868000},"page":"1239-1245","source":"Crossref","is-referenced-by-count":56,"title":["DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia"],"prefix":"10.1111","volume":"44","author":[{"given":"Peter","family":"Valent","sequence":"first","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Ludwig Boltzmann Cluster Oncology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Sadovnik","sequence":"additional","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"R\u00e1\u010dil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology Masaryk University and University Hospital Brno Brno Czech Republic"},{"name":"CEITEC Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Ludwig Boltzmann Cluster Oncology Medical University of Vienna Vienna Austria"},{"name":"Department of Radiotherapy Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Blatt","sequence":"additional","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Cerny\u2010Reiterer","sequence":"additional","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Ludwig Boltzmann Cluster Oncology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Eisenwort","sequence":"additional","affiliation":[{"name":"Division of Haematology &amp; Hemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"},{"name":"Ludwig Boltzmann Cluster Oncology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lion","sequence":"additional","affiliation":[{"name":"Children\u2032s Cancer Research Institute (CCRI) Vienna und Department of Pediatrics Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Holyoake","sequence":"additional","affiliation":[{"name":"College of Medical Veterinary &amp; Life Sciences Institute of Cancer Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology Masaryk University and University Hospital Brno Brno Czech Republic"},{"name":"CEITEC Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401281"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2147"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00025-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330500234195"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404609"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07197.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5745"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-222471"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35721"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326843"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.06.005"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/367645a0"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-730"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.2056"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-077941"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.246"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2010.06.001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07737"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800911793743655"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-202606"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2009.06.001"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.04.003"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.018"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.03.002"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0109"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3368"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.015"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3678"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.6.2162.bloodjournal8862162"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403649"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.720"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004408107"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500272507"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.035006"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-536078"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401875"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-3-259"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.392"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.990"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01746.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704271104"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-083048"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.045"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2811"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118331"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206565"},{"key":"e_1_2_12_50_1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1182\/blood.V122.21.1654.1654","article-title":"Phenotyping of leukemic stem cells in Ph+ ALL and Ph\u2212 ALL reveals unique profiles of markers and targets in distinct disease variants","volume":"122","author":"Cerny\u2010Reiterer S","year":"2013","journal-title":"Blood"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.03.012"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.9995"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2991"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040258"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0092"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-9437-9_14"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.66"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:04:13Z","timestamp":1696363453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/eci.12368"],"URL":"https:\/\/doi.org\/10.1111\/eci.12368","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}