{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:20:30Z","timestamp":1792412430893,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003092","name":"Dutch Diabetes Research Foundation","doi-asserted-by":"crossref","award":["2001.00.012"],"award-info":[{"award-number":["2001.00.012"]}],"id":[{"id":"10.13039\/501100003092","id-type":"DOI","asserted-by":"crossref"}]},{"name":"LipoScience Inc. (Raleigh, NC, USA)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Plasma cholesteryl ester transfer (CET<\/jats:styled-content>), reflecting transfer of cholesteryl esters from high density lipoproteins (HDL<\/jats:styled-content>) towards apolipoprotein B\u2010containing lipoproteins, may promote atherosclerosis development, and is elevated in Type 2 diabetes mellitus (T2DM<\/jats:styled-content>). We determined the extent to which the relationship of plasma CET<\/jats:styled-content> with very low density lipoprotein (VLDL<\/jats:styled-content>) and low density lipoprotein (LDL<\/jats:styled-content>) subfractions is modified in T2DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Plasma CET<\/jats:styled-content>, cholesteryl ester transfer protein (CETP<\/jats:styled-content>) mass, as well as VLDL<\/jats:styled-content> and LDL<\/jats:styled-content> subfractions (nuclear magnetic resonance spectroscopy) were determined in 62 patients with T2DM<\/jats:styled-content> and 53 nondiabetic subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>Plasma CET<\/jats:styled-content> and CETP<\/jats:styled-content> mass were increased in T2DM<\/jats:styled-content>, coinciding higher triglycerides and large VLDL<\/jats:styled-content> particles (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b702). Plasma CET<\/jats:styled-content> was positively related to the VLDL<\/jats:styled-content> and the LDL<\/jats:styled-content> particle concentration in age\u2010, sex\u2010 and diabetes status\u2010adjusted analysis (both P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001). Multivariable linear regression analysis demonstrated an independent positive interaction between the presence of T2DM<\/jats:styled-content> and the VLDL<\/jats:styled-content> concentration on plasma CET<\/jats:styled-content> (\u03b2\u00a0=\u00a00\u00b7238, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7033). The relationship of plasma CET<\/jats:styled-content> with the VLDL<\/jats:styled-content> concentration was also positively modified by plasma glucose (\u03b2\u00a0=\u00a00\u00b7211, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7004) and glycated haemoglobin (\u03b2\u00a0=\u00a00\u00b7190, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7012). Of the individual VLDL<\/jats:styled-content> subfractions, a positive interaction of diabetes status with large VLDL<\/jats:styled-content> on plasma CET<\/jats:styled-content> was observed (\u03b2\u00a0=\u00a00\u00b7280, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7003). Neither the relationship of the LDL<\/jats:styled-content> particle concentration nor of CETP<\/jats:styled-content> mass with plasma CET<\/jats:styled-content> was modified by the presence of T2DM<\/jats:styled-content> (P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0\u00b715).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Abnormalities in the concentration and composition of large VLDL<\/jats:styled-content> particles are likely to contribute to elevated plasma CET<\/jats:styled-content> in T2DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12377","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T11:19:00Z","timestamp":1416223140000},"page":"36-44","source":"Crossref","is-referenced-by-count":19,"title":["Increased large VLDL<\/scp> particles confer elevated cholesteryl ester transfer in diabetes"],"prefix":"10.1111","volume":"45","author":[{"given":"Robin P. 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geesje M.","family":"Dallinga\u2010Thie","sequence":"additional","affiliation":[{"name":"Department of Experimental Vascular Medicine Academic Medical Center Amsterdam the 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