{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:58:02Z","timestamp":1790261882984,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alfediam"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aims of this study were to noninvasively (i) assess the coronary microcirculation changes in response to a cold pressor test (<jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>) in control subjects, nondiabetic obese patients and patients with type 2 diabetes and (ii) investigate the response of the coronary microcirculation in patients with diabetes according to the presence or the absence of silent myocardial ischaemia (<jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content>), asymptomatic coronary stenosis (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) and left ventricle hypertrophy (<jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mean left anterior descending coronary flow velocity (m<jats:styled-content style=\"fixed-case\">CFV<\/jats:styled-content>) was measured using transthoracic Doppler before and after a <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> in 16 control subjects, 11 obese and 66 asymptomatic diabetic patients with a high cardiovascular risk. Patients with diabetes were screened for <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> using stress myocardial scintigraphy and\/or echocardiography. A coronary angiography was performed in those with <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, pressure\u2013rate product (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) was correlated with <jats:styled-content style=\"fixed-case\">mCFV<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b723; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) and left ventricle mass (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b726; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in the whole population. Changes in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">mCFV<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> were correlated with controls (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b758, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), obese (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b775, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and diabetic patients without <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b756, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) or without <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b763, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) but not in diabetic patients with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> or with <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>. In patients with diabetes, <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> was associated with <jats:styled-content style=\"fixed-case\">mCFV<\/jats:styled-content> changes, independent of other parameters (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transthoracic coronary Doppler allows noninvasive study of changes in the coronary microcirculation during <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>. In asymptomatic patients with type 2 diabetes, this method showed that <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> was associated with <jats:styled-content style=\"fixed-case\">mCFV<\/jats:styled-content> changes during <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content> and the presence of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> was associated with a mismatch between coronary microcirculation and myocardial oxygen demand.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12389","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T06:18:38Z","timestamp":1418192318000},"page":"135-143","source":"Crossref","is-referenced-by-count":8,"title":["Noninvasive study of coronary microcirculation response to a cold pressor test"],"prefix":"10.1111","volume":"45","author":[{"given":"Isabelle","family":"Pham","sequence":"first","affiliation":[{"name":"Clinical Physiology Department Jean Verdier Hospital APHP HUPSSD Bondy France"},{"name":"UFR Sant\u00e9, M\u00e9decine, Biologie Humaine EA 2363 \u2018R\u00e9ponses cellulaires et fonctionnelles \u00e0 l'hypoxie\u2019 Sorbonne Paris\u2010Cit\u00e9 Paris 13 University Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh\u2010Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Nutrition Jean Verdier Hospital AP\u2010HP HUPSSD Paris 13 University CRNH\u2010IdF CINFO Bondy France"},{"name":"Unit\u00e9 de Recherche Epid\u00e9miologique Nutritionnelle Paris 13 University Sorbonne Paris\u2010Cit\u00e9 U557 INSERM\/U11125 INRA\/CNAM\/Universit\u00e9 Paris13 Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Valensi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Nutrition Jean Verdier Hospital AP\u2010HP HUPSSD Paris 13 University CRNH\u2010IdF CINFO Bondy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital Unit of Clinical Research Paris 7 University AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Nitenberg","sequence":"additional","affiliation":[{"name":"Clinical Physiology Department Jean Verdier Hospital APHP HUPSSD Bondy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vicaut","sequence":"additional","affiliation":[{"name":"Lariboisi\u00e8re Hospital Unit of Clinical Research Paris 7 University AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Cosson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology\u2010Diabetology\u2010Nutrition Jean Verdier Hospital AP\u2010HP HUPSSD Paris 13 University CRNH\u2010IdF CINFO Bondy France"},{"name":"Unit\u00e9 de Recherche Epid\u00e9miologique Nutritionnelle Paris 13 University Sorbonne Paris\u2010Cit\u00e9 U557 INSERM\/U11125 INRA\/CNAM\/Universit\u00e9 Paris13 Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.08.028"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70060-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03235-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12275"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12242"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.05.020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.192492"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01075.2007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-13-20"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"3S3","article-title":"Identification of myocardial ischemia in the diabetic patient. 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