{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:54:04Z","timestamp":1773035644180,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["New Horizons"],"award-info":[{"award-number":["New Horizons"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Tissue\u2010specific dipeptidyl\u2010peptidase 4 (DPP<\/jats:styled-content>4) dysregulation has been described in adults with diabetes mellitus. The DPP<\/jats:styled-content>4 \u2010incretin system has not been studied in foetal life. In this study, DPP<\/jats:styled-content>4 activity and glucagon\u2010like peptide\u20101 (GLP\u20101<\/jats:styled-content>) levels were assessed in cord blood of neonates born to women with gestational diabetes mellitus (GDM<\/jats:styled-content>) and nondiabetic controls.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>This study has been conducted in two Hungarian and one Austrian centres. Patients:<\/jats:italic> A total of 568 pregnant women were enrolled in the study after their OGTT<\/jats:styled-content> between the 24th and 28th gestational week. Cord blood samplings with DPP<\/jats:styled-content>4 activity and GLP<\/jats:styled-content>\u20101 level measurements were possible in 270 (DPP<\/jats:styled-content>4: 159 control, 111 GDM<\/jats:styled-content>) and 112 (GLP<\/jats:styled-content>\u20101: 72 control, 40 GDM<\/jats:styled-content>) cases. OGTT<\/jats:styled-content> (24\u201328th gestational week) and cord blood sampling at delivery were performed. Cord serum DPP<\/jats:styled-content>4 activity was determined in a continuous monitoring microplate\u2010based kinetic assay, and cord plasma GLP<\/jats:styled-content>\u20101 was measured using a fluorescence ELISA<\/jats:styled-content> method.<\/jats:p><\/jats:sec>Results<\/jats:title>Cord serum DPP<\/jats:styled-content>4 activity was lower in GDM<\/jats:styled-content> [mean (95% CI<\/jats:styled-content>): 28\u00b707\u00a0U\/L (26\u00b732\u201329\u00b782\u00a0U\/L)] than in controls [31\u00b761\u00a0U\/L (29\u00b793\u201333\u00b729\u00a0U\/L), MWU <\/jats:styled-content>P\u00a0<\/jats:italic>=\u00a00\u00b70015]. Cord plasma active GLP<\/jats:styled-content>\u20101 levels were close to the lower detection limit and were not altered in GDM<\/jats:styled-content> (control: mean\u00a0=\u00a03\u00b743\u00a0pM, 95% CI<\/jats:styled-content>: 3\u00b704\u20133\u00b782\u00a0pM, GDM<\/jats:styled-content>: mean\u00a0=\u00a03\u00b761\u00a0pM, 95% CI<\/jats:styled-content>: 2\u00b796\u20134\u00b728\u00a0pM \u2013 MWU<\/jats:styled-content> test P<\/jats:italic>\u00a0=\u00a00\u00b76).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Decreased cord serum DPP<\/jats:styled-content>4 activity in gestational diabetes mellitus might be the result of an adaptive foetal response or an early dysregulation in the entero\u2010insular axis with consequences beyond the incretin system. Cord plasma GLP<\/jats:styled-content>\u20101 levels may reflect the missing oral intake with a limited glucose sensing of L cells via the circulation in foetal life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12397","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T07:05:49Z","timestamp":1420441549000},"page":"196-203","source":"Crossref","is-referenced-by-count":10,"title":["Cord serum dipeptidyl\u2010peptidase 4 activity in gestational diabetes"],"prefix":"10.1111","volume":"45","author":[{"given":"Zahra","family":"Al\u2010Aissa","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Rosta","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"},{"name":"Department of Obstetrics and Fetomaternal Medicine University Hospital 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