{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:26:36Z","timestamp":1789943196229,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess serum soluble triggering receptor expressed on myeloid cells\u20101 (<jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101) levels in disease\u2010modifying antirheumatic drug (<jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>)\u2010na\u00efve early rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>), to investigate the association of <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 levels with Disease Activity Score in 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) and seropositivity for anti\u2010cyclic citrullinated peptide <jats:italic>(<\/jats:italic><jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>) antibody and to determine the predictive value of <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 with respect to clinical response to <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two consecutive patients with <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>\u2010na\u00efve <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> were prospectively evaluated for serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 by means of <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> at diagnosis and at the following clinic visit after prednisone and\/or <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content> has been administered, and related to <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 and serum level of anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibody. We compared the <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 level to that of 31 patients with established <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> as well as to 24 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 level was significantly higher in the <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>\u2010na\u00efve <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> group (2122\u00b79\u00a0\u00b1\u00a0388\u00b79 \u03c1g\/mL) compared to established <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> group (1478\u00b70\u00a0\u00b1\u00a0280\u00b70\u00a0\u03c1g\/mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and normal control (34\u00b74\u00a0\u00b1\u00a07\u00b74 \u03c1g\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). In the <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> group, elevated basal <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 level correlated with higher <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3\u00b723, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b74\u20138\u00b712), <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2\u00b734 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b71\u20138\u00b712), as well as predicted higher <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 score at the following encounter after <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content> treatment was administered (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3\u00b72 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b71\u20137\u00b72). Higher serum level of <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 correlated with higher titres of anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibody (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 may provide a novel biomarker for <jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>\u2010na\u00efve <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content> as well as for seropositivity for anti\u2010<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content> antibody and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12442","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T18:47:46Z","timestamp":1427914066000},"page":"557-564","source":"Crossref","is-referenced-by-count":20,"title":["Soluble triggering receptor expressed on myeloid cells\u20101 is a biomarker of anti\u2010<scp>CCP<\/scp>\u2010positive, early rheumatoid arthritis"],"prefix":"10.1111","volume":"45","author":[{"given":"Yair","family":"Molad","sequence":"first","affiliation":[{"name":"Rheumatology Unit Rabin Medical Center Beilinson Hospital Petach Tikva Israel"},{"name":"Laboratory of Inflammation Research Felsenstein Medical Research Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shachaf","family":"Ofer\u2010Shiber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H Rabin Medical Center Beilinson 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