{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:27:25Z","timestamp":1787657245291,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Adiponectin, an adipose tissue\u2010derived hormone with insulin\u2010sensitizing effect, has been inversely associated with several hormonally dependent malignancies. Prostate cancer is associated with low levels of adiponectin, which have been proposed as an independent risk factor for this malignancy. Aim of this study was to examine whether hypoadiponectinaemia in prostate is associated with insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>Plasma samples and covariate data in the context of a case\u2013control study of 300 Greek men were evaluated including 75 patients with prostate cancer, 75 patients with benign prostatic hyperplasia (<jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content>) and 150 age\u2010matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with prostate cancer had significantly lower plasma adiponectin levels compared with the other two groups, that is <jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content> patients and healthy controls (7\u00b74\u00a0\u00b1\u00a05\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs. 11\u00b75\u00a0\u00b1\u00a06\u00b74\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> and 12\u00b78\u00a0\u00b1\u00a08\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively). On the other hand, no statistically significant differences were found between patients with prostate cancer and the other two groups for both <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7551). As expected, in all three groups, the levels of adiponectin correlated negatively with <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (rho\u00a0=\u00a0\u22120\u00b7214, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7006), <jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content> (rho\u00a0=\u00a00\u00b7214, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7006) and insulin levels (rho\u00a0=\u00a00\u00b7942, <jats:italic>P<\/jats:italic>\u2010value&lt;0\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In spite of what would have been expected from the relevant literature, our data suggest that the hypoadiponectinaemia in prostatic cancer does not appear to be associated with insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12445","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T18:39:12Z","timestamp":1427913552000},"page":"572-578","source":"Crossref","is-referenced-by-count":14,"title":["In prostate cancer, low adiponectin levels are not associated with insulin resistance"],"prefix":"10.1111","volume":"45","author":[{"given":"Konstantinos","family":"Michalakis","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine National and Kapodestrian University of Athens School of Medicine \u2018Laiko\u2019 General Hospital Athens Greece"},{"name":"Department of Clinical Chemistry School of Medicine University of Crete Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Venihaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry School of Medicine University of Crete Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriani","family":"Vazaiou","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics &amp; Diabetes Center P &amp; A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ilias","sequence":"additional","affiliation":[{"name":"Endocrine Department E. Venizelou Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Gryparis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Margioris","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry School of Medicine University of Crete Heraklion Crete 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