{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:32:01Z","timestamp":1789896721350,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa is a common psychiatric disorder in adolescence and is related to cardiovascular complications. Our aim was to study the effect of anorexia nervosa on metabolic parameters, leucocyte\u2013endothelium interactions, adhesion molecules and proinflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This multicentre, cross\u2010sectional, case\u2013control study employed a population of 24 anorexic female patients and 36 controls. We evaluated anthropometric and metabolic parameters, interactions between leucocytes polymorphonuclear neutrophils (<jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content>) and human umbilical vein endothelial cells (<jats:styled-content style=\"fixed-case\">HUVEC<\/jats:styled-content>), proinflammatory cytokines such as tumour necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) and interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) and soluble cellular adhesion molecules (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>s) including E\u2010selectin, vascular cell adhesion molecule\u20101 (<jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101) and intercellular adhesion molecule\u20101 (<jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anorexia nervosa was related to a decrease in weight, body mass index, waist circumference, systolic blood pressure, glucose, insulin and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, and an increase in <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol. These effects disappeared after adjusting for <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Anorexia nervosa induced a decrease in <jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content> rolling velocity and an increase in <jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content> rolling flux and <jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content> adhesion. Increases in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and adhesion molecule <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101 were also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the hypothesis of an association between anorexia nervosa, inflammation and the induction of leucocyte\u2013endothelium interactions. These findings may explain, in part at least, the increased risk of vascular disease among patients with anorexia nervosa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12454","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T07:44:48Z","timestamp":1430898288000},"page":"670-678","source":"Crossref","is-referenced-by-count":23,"title":["Involvement of leucocyte\/endothelial cell interactions in anorexia nervosa"],"prefix":"10.1111","volume":"45","author":[{"given":"V\u00edctor M.","family":"V\u00edctor","sequence":"first","affiliation":[{"name":"Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO) Valencia Spain"},{"name":"Service of Endocrinology University Hospital Doctor Peset Valencia Spain"},{"name":"Institute of Health Research INCLIVA University of Valencia Valencia Spain"},{"name":"Department of Physiology University of Valencia Valencia 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