{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:36:27Z","timestamp":1773009387199,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universit\u00e0 di Milano","award":["PUR 2009"],"award-info":[{"award-number":["PUR 2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Hypogonadism occurs in myotonic dystrophies type 1 (MD<\/jats:styled-content>1) and type 2 (MD<\/jats:styled-content>2). Sertoli and Leydig cell secretions, including insulin\u2010like peptide\u20103 (INSL<\/jats:styled-content>3), anti\u2010M\u00fcllerian hormone (AMH<\/jats:styled-content>) and inhibin B, were evaluated in male patients with MD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design<\/jats:title>Academic settings. Forty\u2010four male patients with MD<\/jats:styled-content> [31 MD<\/jats:styled-content>1, 13 MD<\/jats:styled-content>2, aged 59 (50\u201364) years, median (interquartile range)], age\u2010, sex\u2010 and BMI<\/jats:styled-content>\u2010matched non\u2010MD<\/jats:styled-content> hypogonadal patients (n<\/jats:italic>\u00a0=\u00a014) and healthy controls (n<\/jats:italic>\u00a0=\u00a032). Serum FSH<\/jats:styled-content>, LH<\/jats:styled-content>, inhibin B, AMH<\/jats:styled-content>, testosterone (T) and INSL<\/jats:styled-content>3 were measured; fat and muscle masses were evaluated by DEXA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Overt primary hypogonadism occurred in 29% of patients with MD<\/jats:styled-content>1 and 46% of patients with MD<\/jats:styled-content>2. Considering subclinical forms, the prevalence increased to 69% of MD<\/jats:styled-content>1 and 100% of MD<\/jats:styled-content>2. A half of patients with MD<\/jats:styled-content> experienced symptoms. INSL<\/jats:styled-content>3 levels were unaffected in most patients with MD<\/jats:styled-content>. By contrast, AMH<\/jats:styled-content> and inhibin B were reduced in most patients with MD<\/jats:styled-content> and unrelated to age. Patients with MD<\/jats:styled-content> showed increased body and visceral fat. Free T levels were negatively predicted by fat mass, and AMH<\/jats:styled-content> and FSH<\/jats:styled-content> levels were negatively correlated with waist\/hip ratio and fat mass. AMH<\/jats:styled-content>, inhibin B and FSH<\/jats:styled-content> levels positively correlated with muscle strength and muscle mass.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>AMH<\/jats:styled-content> and inhibin B secretion failures are common in male patients with MD<\/jats:styled-content> and are more severe than Leydig cell hormones impairment. AMH<\/jats:styled-content> and inhibin B measurements might provide clinical utility in evaluating fertility in patients with MD<\/jats:styled-content>. Serum T, AMH<\/jats:styled-content> and inhibin B productions are negatively influenced by increased fat mass, while AMH<\/jats:styled-content> and inhibin B might be markers of muscle impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12459","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T11:55:54Z","timestamp":1430999754000},"page":"702-710","source":"Crossref","is-referenced-by-count":21,"title":["Gonadal failure is associated with visceral adiposity in myotonic dystrophies"],"prefix":"10.1111","volume":"45","author":[{"given":"Elena","family":"Passeri","sequence":"first","affiliation":[{"name":"Endocrinology Unit Department of Biomedical Sciences for Health University of Milan IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Bugiardini","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Biomedical Sciences for Health University of Milan IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria A.","family":"Sansone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health NEuroMuscular Omnicentre (NEMO) Fondazione Serena Onlus University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pizzocaro","sequence":"additional","affiliation":[{"name":"Urology Unit IRCCS Istituto Clinico Humanitas Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Fulceri","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory IRCCS Policlinico San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rea","family":"Valaperta","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory IRCCS Policlinico San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Borgato","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Metabolic Diseases IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Costa","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory IRCCS Policlinico San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bandera","sequence":"additional","affiliation":[{"name":"Heart Failure Unit IRCCS Policlinico San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Ambrosi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Department of Biomedical Sciences for Health University of Milan IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Meola","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Biomedical Sciences for Health University of Milan IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Persani","sequence":"additional","affiliation":[{"name":"Division of Endocrine and Metabolic Diseases IRCCS Istituto Auxologico Italiano Milan Italy"},{"name":"Department of Clinical Science and Community Health University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Department of Biomedical Sciences for Health University of Milan IRCCS Policlinico San Donato San Donato Milanese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Myotonic Dystrophy 2001","author":"Harper PSH"},{"key":"e_1_2_8_3_1","first-page":"1993","volume-title":"Gene Reviews","author":"Dalton JC","year":"2006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.1.170"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00649-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.158261"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.05.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh161"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350681"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01995710"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000054481.84978.F9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.2.134"},{"key":"e_1_2_8_13_1","first-page":"142","article-title":"Myotonic dystrophy presenting as male infertility: a case report","volume":"32","author":"Futterweit W","year":"1987","journal-title":"Int J Fertil"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.10.1269"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2012.00008.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2011.138"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.05.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2749"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02339.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/958510"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4081\/918"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00262.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.09.001"},{"key":"e_1_2_8_26_1","unstructured":"Medical Research Council.Aids to the examination of the peripheral nervous system 1976 Memorandum 45 Pendragon House London."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.336"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0203"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2582"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318226046b"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.016"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1345164"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.10.016"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2011.01185.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2354"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.2.219"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060080063017"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:26:31Z","timestamp":1696292791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/eci.12459"],"URL":"https:\/\/doi.org\/10.1111\/eci.12459","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}