{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:38:28Z","timestamp":1771036708643,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taipei Medical University and Shuang-Ho Hospital","award":["103TMU-SHH-03"],"award-info":[{"award-number":["103TMU-SHH-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of autoimmune thyroid disease (<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>) is known to have a major adverse effect on interferon (<jats:styled-content style=\"fixed-case\">INF<\/jats:styled-content>)\u2010\u03b1 treatment. The genetic variant of the <jats:styled-content style=\"fixed-case\">INF<\/jats:styled-content> regulatory factor 8 (<jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8), a type 1 <jats:styled-content style=\"fixed-case\">INF<\/jats:styled-content> regulator, is associated with susceptibility to systemic lupus erythematosus and multiple sclerosis. In this study, we investigated possible associations of the <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8 polymorphisms, rs17445836 and rs2280381, with <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content> in an ethnic Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In total, 278 patients with Graves' disease (<jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content>) and 55 patients with Hashimoto's thyroiditis (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>), and 252 healthy controls were enrolled. Polymerase chain reaction\u2010restriction fragment length polymorphism (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content>) and direct sequencing were used for genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly lower frequencies of the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype and A allele of rs17445836 were found in the <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> group than in the control group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7028, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a04\u00b771 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7022, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04\u00b740, respectively). Both rs17445836 and rs2280381 were associated with the presence of an antimicrosomal antibody (AmiA), and rs2280381 was also associated with the presence of an antithyroglobulin antibody (<jats:styled-content style=\"fixed-case\">ATA<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>. Moreover, rs17445836 was associated with the level of AmiA in <jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rs17445836 of <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>8 is a possible genetic variant associated with the development of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>. rs17445836 was associated with the production of thyroid antibody, and the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of rs17445836 was associated with a higher AmiA titre than the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12463","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T08:30:50Z","timestamp":1432110650000},"page":"711-719","source":"Crossref","is-referenced-by-count":19,"title":["Association of <scp>IRF<\/scp>8 gene polymorphisms with autoimmune thyroid disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Jiunn\u2010Diann","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Division of Endocrinology Department of Internal Medicine Shuang\u2010Ho Hospital School of Medicine College of Medicine Taipei Medical University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Urology Shuang\u2010Ho Hospital School of Medicine College of Medicine Taipei Medical University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Shuang\u2010Ho Hospital School of Medicine College of Medicine Taipei Medical University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Chin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Shuang\u2010Ho Hospital School of Medicine College of Medicine Taipei Medical University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010An","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Division of Nephrology Department of Internal Medicine Shuang\u2010Ho Hospital School of Medicine College of Medicine Taipei Medical University New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam\u2010Tsun","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Veterans General Hospital National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8302-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031693"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364059"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502321085234"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6071"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2434175100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21146"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00394-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04904-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-5-1086"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.11.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.07.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.07.006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.42"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002341"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12087"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.09.032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.401"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8055-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32832cf824"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500605"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.208"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2148"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:26:32Z","timestamp":1696292792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,15]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/eci.12463"],"URL":"https:\/\/doi.org\/10.1111\/eci.12463","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,15]]}}}