{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:14:23Z","timestamp":1773418463505,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi\u2010Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004324","name":"Astellas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Atrial fibrillation (AF<\/jats:styled-content>) is associated with high morbidity and mortality, even despite the use of oral anticoagulation (OAC<\/jats:styled-content>). Soluble suppression of tumorigenicity\u20102 (sST<\/jats:styled-content>2) is a member of the interleukin\u20101 receptor family [interleukin\u20101 receptor\u2010like 1 (IL<\/jats:styled-content>1RL<\/jats:styled-content>1)], which has been associated with an increased risk of mortality and morbidity in heart failure or acute coronary syndrome. We assessed the predictive value of sST<\/jats:styled-content>2 levels in an unselected \u2018real\u2010world\u2019 cohort of anticoagulated AF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included 562 patients (49% male; median age 77 [IQR<\/jats:styled-content>: 71\u201382]) with permanent AF<\/jats:styled-content> who were stable (for at least 6\u00a0months) on OAC<\/jats:styled-content> (INR<\/jats:styled-content>s 2\u00b70\u20133\u00b70). sST<\/jats:styled-content>2 levels were quantified by ELISA<\/jats:styled-content>. Patients were followed\u2010up for up to 4\u00a0years, and cardiovascular events and all\u2010cause mortality were recorded.<\/jats:p><\/jats:sec>Results<\/jats:title>Median (IQR<\/jats:styled-content>) of sST<\/jats:styled-content>2 levels was 51\u00b723 (39\u00b709\u201367\u00b740)\u00a0\u03bcg\/L. Median follow\u2010up was 1587\u00a0days [IQR<\/jats:styled-content> 1482\u20131617], and during this period, 91 patients died (16\u00b72%, 3\u00b772%\/year). The c\u2010statistic for predicting mortality with sST<\/jats:styled-content>2 was 0\u00b758\u00a0+\u00a00\u00b703; P<\/jats:italic>\u00a0=\u00a00\u00b7017). On multivariate analysis, age [hazard ratio (HR<\/jats:styled-content>) 1\u00b709 (1\u00b705\u20131\u00b713); P<\/jats:italic>\u00a0<\u00a00\u00b7001], diabetes mellitus [1\u00b776 (1\u00b708\u20132\u00b788); P<\/jats:italic>\u00a0=\u00a00\u00b7023], previous stroke [2\u00b716 (1\u00b729\u20133\u00b760); P<\/jats:italic>\u00a0=\u00a00\u00b7003] and sST<\/jats:styled-content>2 levels [1\u00b7008 (1\u00b7002\u20131\u00b714); P<\/jats:italic>\u00a0=\u00a00\u00b7008] were independently associated with mortality. Concentrations of sST<\/jats:styled-content>2 were also significantly associated with the risk of mortality, even after adjusting for the CHA<\/jats:styled-content>2<\/jats:sub>DS<\/jats:styled-content>2<\/jats:sub>\u2013VAS<\/jats:styled-content>c score [HR<\/jats:styled-content>: 1\u00b7007 (1\u00b7001\u20131\u00b7013); P<\/jats:italic>\u00a0=\u00a00\u00b7014].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In an anticoagulated AF<\/jats:styled-content> patient's cohort, sST<\/jats:styled-content>2 levels are an independent predictive factor of all\u2010cause mortality. sST<\/jats:styled-content>2 levels could be a biomarker used to improve clinical risk assessment in anticoagulated AF<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12482","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T07:37:30Z","timestamp":1434526650000},"page":"899-905","source":"Crossref","is-referenced-by-count":21,"title":["sST2 levels are associated with all\u2010cause mortality in anticoagulated patients with atrial fibrillation"],"prefix":"10.1111","volume":"45","author":[{"given":"Juan A.","family":"V\u00edlchez","sequence":"first","affiliation":[{"name":"Departments of Cardiology and Clinical Analysis Clinic University Hospital Virgen de la Arrixaca IMIB\u2010Arrixaca Murcia Spain"},{"name":"Department of Biochemistry and Molecular Biology Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"P\u00e9rez\u2010Cuellar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Universitat Aut\u00f2noma Barcelona Spain"},{"name":"Red de Investigaci\u00f3n Cardiovascular Instituto de Salud Carlos III Madrid Spain"},{"name":"IIB\u2010Sant Pau Biomedical Research Institute Hospital Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Cardiovascular Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Cardiology of Clinic University Hospital Virgen de la Arrixaca IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Gallego","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Unit General University Hospital Morales Meseguer Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Manzano\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Cardiovascular Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Cardiology of Clinic University Hospital Virgen de la Arrixaca IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Cardiovascular Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Cardiology of Clinic University Hospital Virgen de la Arrixaca IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Vicente","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Cardiovascular Instituto de Salud Carlos III Madrid Spain"},{"name":"Hematology and Medical Oncology Unit General University Hospital Morales Meseguer Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Noguera\u2010Velasco","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y. 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