{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:29:38Z","timestamp":1776223778081,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["RP\u2010010\u20102012A"],"award-info":[{"award-number":["RP\u2010010\u20102012A"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\u2010MOHE\/ASH\/02"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\u2010MOHE\/ASH\/02"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A drop in postural blood pressure (BP) may contribute to falls, while antihypertensives have been considered to induce postural drop or orthostatic hypotension (OH) and falls among older people. However, this relationship between antihypertensives, postural BP and the risk of falls has never been evaluated in a single study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association of postural BP changes and BP therapy with the risk of falls among community\u2010dwelling older people in a case\u2013control manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a0202) included participants aged \u2265\u00a065\u00a0years with two falls or one injurious fall while controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a0156) included participants \u2265\u00a065\u00a0years with no falls in the preceding 12\u00a0months. Antihypertensives usage and medical history were recorded. Supine BP measurements were obtained at 10\u00a0min rest and at 1, 2 and 3\u00a0min after standing. Orthostatic hypotension was defined as a reduction in BP of 20\/10\u00a0mmHg within 3\u00a0min of standing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual antihypertensive classes were not associated with falls. Minimal standing systolic BP (SBP) was significantly lower among fallers [128 (\u00b1\u00a027\u00b73) vs. 135\u00b77 (\u00b1\u00a024\u00b77)\u00a0mmHg; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701], but fallers were not more likely to fulfil the diagnostic criteria for OH. Diuretics were associated with OH and \u03b1\u2010blockers were associated with minimal standing SBP. Univariate analysis revealed that the use of \u2265\u00a02 antihypertensives was associated with recurrent and injurious falls [OR,1.97;CI,1.2\u20133.1], which was no longer significant aftermultivariateadjustment for age and number of comorbidities [OR, 1.6; CI, 0.95\u20132.6].<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Minimal standing SBP or a lower SBP at 2 or 3minutes standing was associated with falls rather than OH using consensus definition. Association between \u2265\u00a02 antihypertensives and falls was attenuated by increasing age and comorbidities. Our findings challenge previous assumptions that OH or the use of antihypertensives is associated with falls. Future studies should now seek to link these findings prospectively with falls in order to guide decision\u2010making for BP lowering therapy among older patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12508","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T15:23:43Z","timestamp":1438010623000},"page":"1069-1076","source":"Crossref","is-referenced-by-count":26,"title":["The association of antihypertensives with postural blood pressure and falls among seniors residing in the community: a case\u2013control study"],"prefix":"10.1111","volume":"45","author":[{"given":"Anam","family":"Zia","sequence":"first","affiliation":[{"name":"Ageing and Age\u2010Associated Disorders Research Group University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrul B.","family":"Kamaruzzaman","sequence":"additional","affiliation":[{"name":"Ageing and Age\u2010Associated Disorders Research Group University of Malaya Kuala Lumpur Malaysia"},{"name":"Department of Medicine Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyo K.","family":"Myint","sequence":"additional","affiliation":[{"name":"AGEING Epidemiology Group School of Medicine &amp; Dentistry Institute of Applied Health Sciences University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maw P.","family":"Tan","sequence":"additional","affiliation":[{"name":"Ageing and Age\u2010Associated Disorders Research Group University of Malaya Kuala Lumpur Malaysia"},{"name":"Department of Medicine Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHOGlobalreport.WHO Global Report on Falls Prevention in Older Age.2007. 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