{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:34:04Z","timestamp":1758706444722},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Hyaluronic acid (HA<\/jats:styled-content>), ASAT<\/jats:styled-content> to Platelet Ratio Index (APRI<\/jats:styled-content>), ASAT<\/jats:styled-content>\/ALAT<\/jats:styled-content> ratio, Fibrosis 4 score (FIB<\/jats:styled-content>4) and FibroScan were studied as non\u2010invasive markers of liver fibrosis (F) in chronic viral hepatitis B (CHB<\/jats:styled-content>) and C (CHC<\/jats:styled-content>), in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of F. The aim of our research was to study whether HA<\/jats:styled-content>, APRI<\/jats:styled-content>, ASAT<\/jats:styled-content>\/ALAT<\/jats:styled-content> ratio, FIB<\/jats:styled-content>4 and FibroScan are useful non\u2010invasive markers in predicting severe F in Romanian patients.<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>This was a prospective multicenter transversal and observational study, which included 76 patients with CHB<\/jats:styled-content>\/CHC<\/jats:styled-content>. The independent effect of studied markers was tested using multiple binary logistic regression.<\/jats:p><\/jats:sec>Results<\/jats:title>In patients with CHB<\/jats:styled-content> and CHC<\/jats:styled-content>, the APRI<\/jats:styled-content> cut\u2010off value for F4 was 0\u00b770 ng\/mL<\/jats:styled-content> (Se = 77%, Sp = 78%), the FIB<\/jats:styled-content>4 cut\u2010off value was 2\u00b701 (Se = 77%, Sp = 69%), and the FibroScan cut\u2010off value was 13\u00b715 (Se = 92%, Sp = 88%). For patients with CHB<\/jats:styled-content>\/CHC<\/jats:styled-content>, there was a significant linear positive correlation between F and HA<\/jats:styled-content> (r<\/jats:italic> = 0\u00b742, P<\/jats:italic> = 0\u00b7001), FibroScan (r<\/jats:italic> = 0\u00b767, P<\/jats:italic> < 0\u00b7001), APRI<\/jats:styled-content> (r<\/jats:italic> = 0\u00b746, P<\/jats:italic> < 0\u00b7001) and FIB<\/jats:styled-content>4 (r<\/jats:italic> = 0\u00b751, P<\/jats:italic> < 0\u00b7001). Considering age, sex and body mass index as possible confounding factors or covariates in multivariable logistic modelling, FibroScan was the unique test that able to significantly highlight the presence of F4 score in CHB<\/jats:styled-content>\/CHC<\/jats:styled-content> patients (P<\/jats:italic> = 0\u00b7009) while FIB<\/jats:styled-content>4 test seems to have a tendency to statistical significance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>FibroScan, APRI<\/jats:styled-content> and FIB<\/jats:styled-content>4 are useful non\u2010invasive tests for the evaluation of F4 in patients with CHB<\/jats:styled-content> and CHC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12543","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T22:54:54Z","timestamp":1443740094000},"page":"1243-1251","source":"Crossref","is-referenced-by-count":14,"title":["Non\u2010invasive assessment of liver fibrosis in chronic viral 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