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Functional gastrointestinal disorders (<jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>s) present with no obvious pathology or well\u2010accepted biochemical mechanism and, as such, treatment strategies are limited and focus on symptoms rather than cure. Irritable bowel syndrome and functional dyspepsia are the most widely recognised <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>s, and there is a growing body of evidence to suggest an underlying inflammatory phenotype in subsets with these conditions. Here, we discuss the current knowledge of immune involvement in <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>s and the commonalities between the different manifestations of <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>s and propose a new hypothesis, potentially defining an underlying immunopathological basis of these conditions.<\/jats:p>","DOI":"10.1111\/eci.12548","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T17:38:43Z","timestamp":1444239523000},"page":"1350-1359","source":"Crossref","is-referenced-by-count":82,"title":["Immune dysregulation in the functional gastrointestinal disorders"],"prefix":"10.1111","volume":"45","author":[{"given":"Simon","family":"Keely","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences &amp; Pharmacy University of Newcastle &amp; Vaccine and Asthma (VIVA) Program Hunter Medical Research Institute Callaghan NSW 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