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This study aimed to investigate the response of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and metabolic profiles to short\u2010term thiazide treatment in an Asian cohort with different hypertension subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Serial ethnic Chinese nondiabetic subjects with hypertension were evaluated. After diet instruction and lifestyle modification for 2 weeks, patients who still had elevated systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\u2265140 mmHg) and\/or diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>\u226590 mmHg) were given 50 mg of hydrochlorothiazide daily for 2 weeks. The responses of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and metabolic profiles were evaluated before and after treatment according to the patient's baseline <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> subtype \u2013 isolated systolic hypertension (<jats:styled-content style=\"fixed-case\">ISH<\/jats:styled-content>), systo\u2010diastolic hypertension (<jats:styled-content style=\"fixed-case\">SDH<\/jats:styled-content>) and isolated diastolic hypertension (<jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hydrochlorothiazide treatment significantly reduced the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in all 92 patients (62 males, aged 45\u00b77 \u00b1 9\u00b76 years), irrespective of their baseline <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> subtypes. In patients with <jats:styled-content style=\"fixed-case\">SDH<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 39) or <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 40), hydrochlorothiazide treatment significantly increased serum adiponectin (<jats:italic>P<\/jats:italic> = 0\u00b7001 and 0\u00b7007, respectively) and reduced asymmetric dimethylarginine levels (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001, in both groups). Serum cholesterol (<jats:italic>P<\/jats:italic> = 0\u00b7027) and fasting blood sugar levels (<jats:italic>P<\/jats:italic> = 0\u00b7044) were significantly improved only in the <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content> patients. Furthermore, <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content> was independently associated with changes in fasting blood sugar (\u03b2 = \u221211\u00b7178, <jats:italic>P<\/jats:italic> = 0\u00b7022) and cholesterol (\u03b2 = \u221222\u00b7654, <jats:italic>P<\/jats:italic> = 0\u00b7027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The characteristics of the Asian hypertensive patients with diastolic hypertension can present a favourable metabolic response to the short\u2010term hydrochlorothiazide treatment. The potential positive effect on cardiovascular risk should be validated in long\u2010term studies in this diastolic type of hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12571","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T14:18:42Z","timestamp":1447942722000},"page":"80-91","source":"Crossref","is-referenced-by-count":3,"title":["Hypertension subtypes modify metabolic response to thiazide diuretics"],"prefix":"10.1111","volume":"46","author":[{"given":"Chin\u2010Chou","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Bang","family":"Leu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Healthcare and Management Center Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Hsun","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Endocrinology and Metabolism Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing\u2010Jong","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaw\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2534"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/jama.1993.03510060059034","article-title":"Treatment of Mild Hypertension Study. 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