{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:22:33Z","timestamp":1777036953561,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["WSN\u2010067"],"award-info":[{"award-number":["WSN\u2010067"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heart rate deceleration capacity and acceleration capacity are novel autonomic nervous system indicators of cardiac neural regulation. Dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>) changes cardiac electrophysiology; however, how deceleration capacity and acceleration capacity associated with <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>To evaluate the association between heart rate acceleration capacity, deceleration capacity and <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>, 66 <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> and 209 controls were enrolled in the study. Demographic data, echocardiographic data, heart rate variability, deceleration capacity and acceleration capacity were collected. The association pattern between <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> and these indexes were studied by multiple logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Deceleration capacity and acceleration capacity were independent risk factors for <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> with an odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), determined by multiple logistic regression analysis, of 7\u00b797 (3\u00b787\u201316\u00b742) and 0\u00b709 (0\u00b705\u20130\u00b719), respectively. Univariate ordinal logistic regression analysis showed that acceleration capacity, fastest heart rate, standard deviation of normal\u2010to\u2010normal <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> intervals (<jats:styled-content style=\"fixed-case\">SDNN<\/jats:styled-content>) and left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LEVF<\/jats:styled-content>) associated with heart failure grade. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for each covariate was further adjusted for the effects of other significant covariates in multivariate ordinal logistic regression analysis. Acceleration capacity, fastest heart rate and <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> were still independent risk factors in the final equation with <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s of 1\u00b732 (1\u00b703\u20131\u00b779), 1\u00b704 (0\u00b701\u20131\u00b707) and 0\u00b746 (0\u00b723\u20130\u00b793), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Heart rate acceleration capacity and deceleration capacity are independent risk factors for <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>, and acceleration capacity is a predictive factor for heart failure exacerbation in patients with <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12594","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T07:22:40Z","timestamp":1453533760000},"page":"312-320","source":"Crossref","is-referenced-by-count":20,"title":["Heart acceleration and deceleration capacities associated with dilated cardiomyopathy"],"prefix":"10.1111","volume":"46","author":[{"given":"Cao","family":"Zou","sequence":"first","affiliation":[{"name":"Cardiology Department First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkai","family":"Dong","sequence":"additional","affiliation":[{"name":"Cardiology Department First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiology Department First Affiliated Hospital of 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