{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:42:45Z","timestamp":1696408965033},"reference-count":84,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>According to epidemiological studies, there is no clear relationship between the plasma cholesteryl ester transfer protein (<jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content>) concentration and the development of atherosclerosis in human populations. Although some studies suggest that increased <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> activity relates to undesirable profiles of plasma lipoproteins, promoting an anti\u2010atherogenic plasma lipoprotein profile by drugs that inhibit <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> has not succeeded in preventing atherosclerosis in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This review describes 28 investigations in human populations dealing with plasma <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content>, 11 in mice that express human <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> and seven in animals (six in rabbits and one in mice) in which plasma <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> activity was inhibited by drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Present review shows that models in mice expressing human <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> are not illuminating because they report increase as well reduction of atherosclerosis. However, investigations in rabbits and mice that develop severe hypercholesterolaemia clearly indicate that impairment of the plasma <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> activity elicits protection against the development of atherosclerosis; in all of these experiments are attained substantial reductions of the atherogenic lipoproteins, namely, plasma apoB containing lipoproteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These models are strong indicators that the benefit in preventing atherosclerosis should be earned in cases of hyperlipidemia by <jats:styled-content style=\"fixed-case\">CETP<\/jats:styled-content> inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12626","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T14:42:59Z","timestamp":1458398579000},"page":"581-589","source":"Crossref","is-referenced-by-count":3,"title":["The controversy over the use of cholesteryl ester transfer protein inhibitors: is there some light at the end of the tunnel?"],"prefix":"10.1111","volume":"46","author":[{"given":"Eder C. R.","family":"Quint\u00e3o","sequence":"first","affiliation":[{"name":"Internal Medicine University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.448"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.08.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2014.0265"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.014026"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.4396.1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207142"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2257-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.05.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2322"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.03.026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.01.052"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060088"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0009-8981(02)00128-6","article-title":"CETP gene mutation (D442G) increases low\u2010density lipoprotein particle size in patients with coronary heart disease","volume":"2","author":"Wang J","year":"2002","journal-title":"Clin Chim Acta"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00859.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.15.2030"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.045"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.23.2777"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00653-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.10.010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01674.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118751"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300520-JLR200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231803"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.875013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.6.985"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117537"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.12.011"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960190608"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00476-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000141730.65972.95"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.17305\/bjbms.2011.2569","article-title":"Cholesteryl ester transfer protein, low density lipoprotein particle size and intima media thickness in patients with coronary heart disease","volume":"11","author":"Tosheska K","year":"2011","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.11.020"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.12.024"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.03.020"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01281.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801083380203"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.872705"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.03.057"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02313.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.01.046"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12248"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90144-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071359"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009744"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206797"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60158-1"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070635"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1649"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80025"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.4.1105"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/364073a0"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000243925.65265.3c"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.02.038"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4743"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.36912"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118255"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M100440-JLR200"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000259357.42089.dc"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.220483"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600135-JLR200"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2005.apm1130106.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.205153"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600332-JLR200"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/35018119"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.9.2106"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.5033"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.037"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111529"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.761965"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.05.036"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.05.007"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.704254"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.06.022"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M016410"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm087"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00344.x"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000161928.16334.dd"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.124"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M055053"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140303152132"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2011.614946"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31816e30fd"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02269.x"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:17:44Z","timestamp":1696357064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/eci.12626"],"URL":"https:\/\/doi.org\/10.1111\/eci.12626","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]}}}