{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:01:39Z","timestamp":1792098099381,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T00:00:00Z","timestamp":1461974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secreted frizzled\u2010related protein (Sfrp)5 improves insulin sensitivity, but impairs beta\u2010cell function in rodents. However, the relationship between Sfrp5, insulin sensitivity and secretion in humans is currently unclear. Therefore, the aim of the study was to characterize the associations between serum Sfrp5 and indices of insulin sensitivity and beta\u2010cell function from dynamic measurements using oral glucose tolerance tests (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This study enrolled 194 individuals with nonalcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>), who were diagnosed based on ultrasound and liver transaminases and underwent a frequent sampling 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>. Fasting serum Sfrp5 was measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Associations were assessed with several indices of insulin sensitivity and beta\u2010cell function derived from glucose, insulin and C\u2010peptide concentrations during the <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating Sfrp5 associated inversely with the insulinogenic index based on C\u2010peptide (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120\u00b7244, <jats:italic>P<\/jats:italic> = 0\u00b7001), but not with the insulinogenic index based on insulin levels (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120\u00b7007, <jats:italic>P<\/jats:italic> = 0\u00b7926) after adjustment for age, sex and body mass index. Sfrp5 inversely correlated only with <jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content> as a marker of insulin sensitivity in the model adjusted for age and sex (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120\u00b7149, <jats:italic>P<\/jats:italic> = 0\u00b7039). These associations were not influenced by the additional adjustment for hepatic steatosis index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The inverse association of serum Sfrp5 with beta\u2010cell function suggests a detrimental role of Sfrp5 for insulin secretion also in humans. The severity of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> does not appear to affect this relationship. The weak association between serum Sfrp5 and insulin sensitivity was partially explained by body mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12629","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T14:42:55Z","timestamp":1459176175000},"page":"535-543","source":"Crossref","is-referenced-by-count":22,"title":["Sfrp5 associates with beta\u2010cell function in humans"],"prefix":"10.1111","volume":"46","author":[{"given":"Maren","family":"Carstensen\u2010Kirberg","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD) M\u00fcnchen\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erifili","family":"Hatziagelaki","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine Research 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