{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:25:19Z","timestamp":1780597519065,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (<jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>) is an effective percutaneous treatment for high\u2010risk patients with severe symptomatic aortic stenosis. However, <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> is rendered less effective in patients with noncalcified aortic valve disease because noncalcified aortic valves lack an anchor site for the implanted stent, causing the stent to relocate to an unexpected position. In this study, we developed an improved <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> with a snare loop\u2010assisted device, and evaluated the feasibility and safety of this strategy in noncalcified aortic valve disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The balloon\u2010expandable valve stent made of cobalt\u2013chromium alloy was cut into a cylindrically shaped mesh configuration. The prosthetic valve was made of bovine pericardium. Ten healthy sheep (six males and four females with an average weight of 27\u00b78 \u00b1 1\u00b718 kg) were selected to undergo transcatheter implantation of valved stents using the snare loop\u2010assisted device. Aortic angiography and colour Doppler echocardiography were applied to assess the function of artificial valves immediately and 3 months after the operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The snare loop\u2010assisted <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> was successfully implanted in all 10 sheep. The aortogram showed that the valve stent was fixed in the expected position. Among these 10 sheep, nine sheep survived for more than 3 months normally and one sheep died of infective endocarditis 1 week after the operation. Ultrasound and aortogram in the 3 months after operation showed proper positions of the prosthetic valves without stenosis and other apparent complications, and normal coronary artery openings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The snare loop\u2010assisted <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> approach can reduce stent shifting during valve stent implantation and improve the success rate of the <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> in those with noncalcified aortic valves.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12653","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T22:51:10Z","timestamp":1466635870000},"page":"714-720","source":"Crossref","is-referenced-by-count":5,"title":["Improved transcatheter aortic valve implantation for aortic regurgitation using a snare loop\u2010assisted device: the first preclinical experience"],"prefix":"10.1111","volume":"46","author":[{"given":"Xiang","family":"Chen","sequence":"first","affiliation":[{"name":"Cardiovascular Therapeutic Centre The 117 Hospital of the Chinese People's Liberation Army Hangzhou China"},{"name":"Department of Cardiology ZhongShan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of cardiothoracic surgery Guangzhou General Hospital of Guangzhou Military Area Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwen","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology ZhongShan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.03.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9SSA11"},{"key":"e_1_2_7_7_1","unstructured":"TestaL BrambillaN LatibA De MarcoF OregliaJ AgnifiliMet al.CoreValve implantation for severe aortic regurgitation: a multicentre registry. 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