{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:03:50Z","timestamp":1760299430535,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary focal segmental glomerulosclerosis (<jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>) is a common cause of nephrotic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The pathogenic steps leading to primary <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content> are still obscure, although evidence suggests that circulatory factor(s) are involved in the onset of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recent technical advances allow the analysis of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression in tissues and body fluids, leading to reports of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s involved in the molecular mechanisms of <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>\u2010aetiopathogenesis. Moreover, investigations have also highlighted mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that might serve as biomarkers for primary <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion\/Conclusions<\/jats:title><jats:p>The aim of this review was to summarize reports showing a direct relation between mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and primary <jats:styled-content style=\"fixed-case\">FSGS<\/jats:styled-content>. In addition, the impact of identified mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s on treatment response, prediction of the disease onset as well as the regulation in different disease activities is summarized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12676","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T09:08:56Z","timestamp":1474448936000},"page":"954-964","source":"Crossref","is-referenced-by-count":6,"title":["Primary focal segmental glomerulosclerosis: mi<scp>RNA<\/scp>s and targeted therapies"],"prefix":"10.1111","volume":"46","author":[{"given":"Johannes","family":"Leierer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV (Nephrology and Hypertension) Medical University Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV (Nephrology and 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