{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:23:32Z","timestamp":1761989012569},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001277","name":"John R. Oishei Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001571","name":"James H. Cummings Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electric stimulation (E\u2010stim) has been found to be an effective treatment in improving wound healing rates. However, the wound healing trajectory and its related predictors for complete wound closure (<jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content>) have not been reported with E\u2010stim treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was a retrospective study. Data on 159 patients treated at an outpatient wound clinic utilizing combined intervention of E\u2010stim and conventional care were included. The Kaplan\u2013Meier healing curve together with linear regression models depicted the percentage of patients with <jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content> against time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With 100, 112 and 140 days of treatment, the percentages of patients with <jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content> were 59\u00b712%, 61\u00b701% and 65\u00b741%, respectively. Linear regression models predicted that all patients would achieve <jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content> by 21\u00b755, 22\u00b726 and 24\u00b780 weeks, respectively. The speed for the increase in the number and percentage of patients with <jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content> peaked between 50\u201375 days of treatment. To optimize timely healing, referral to other treatment facilities or change of treatment protocol is warranted around the peak time. With the combined intervention of E\u2010stim and conventional care, positive predictors for <jats:styled-content style=\"fixed-case\">CWC<\/jats:styled-content> included a shorter wound duration at initial evaluation (<jats:italic>P<\/jats:italic> = 0\u00b7005, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3\u00b710), better compliance with appointments (<jats:italic>P<\/jats:italic> = 0\u00b7007, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3\u00b738) and the diagnosis of venous leg ulcer (<jats:italic>P<\/jats:italic> = 0\u00b7001, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3\u00b788).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provided preliminary data on wound healing trajectory and predictors with combined E\u2010stim and conventional care. E\u2010stim seemed to expedite wound healing; however, further research studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12685","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T22:30:42Z","timestamp":1476311442000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":5,"title":["The wound healing trajectory and predictors with combined electric stimulation and conventional care: one outpatient wound care clinic's experience"],"prefix":"10.1111","volume":"46","author":[{"given":"Kehua","family":"Zhou","sequence":"first","affiliation":[{"name":"Physical Therapy Wound Care Clinic Daemen College Amherst NY USA"},{"name":"Department of Health Promotion Daemen College Amherst NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Schenk","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Daemen College Amherst NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Brogan","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Daemen College Amherst NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690040093015"},{"key":"e_1_2_9_3_1","unstructured":"European Wound Management Association (EWMA).Position Document: Hard\u2010to\u2010heal wounds: a holistic approach.London:MEP Ltd;2008."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/819525"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00174.x"},{"key":"e_1_2_9_6_1","unstructured":"Scottish Intercollegiate Guidelines Network.Management of Chronic Venous Leg Ulcers. 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