{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:17:36Z","timestamp":1785838656237,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies suggested that obesity could negatively affect the response to antitumour necrosis factor\u2010\u03b1 (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1) agents in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>). However, data are lacking on whether obesity affects the response to abatacept (<jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>). We aimed to determine whether body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) affects the response to <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this multicenter retrospective study, we included <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients who received <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was calculated at the initiation of treatment. After 6 months of treatment, change from baseline in <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28, pain on a visual analog scale, erythrocyte sedimentation rate and C\u2010reactive protein level, tender and swollen joint count were analysed. The primary endpoint was decrease in <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 \u2265 1\u00b72. Secondary outcomes were good response and remission by <jats:styled-content style=\"fixed-case\">EULAR<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, among 141 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients included, the median [interquartile range] <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was 26\u00b70 [22\u00b79\u201330\u00b78] kg\/m\u00b2. The number of patients with normal weight, overweight and obesity was 64 (45\u00b74%), 38 (27%) and 39 (27\u00b76%), respectively. Baseline characteristics did not differ among the three <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> subgroups. Univariate analysis revealed no difference in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> between responders and nonresponders: <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28 decrease \u2265 1\u00b72 (25\u00b70 [23\u00b74\u201331\u00b73] vs. 26\u00b73 [22\u00b79\u201330\u00b72], <jats:italic>P<\/jats:italic> = 0\u00b795), <jats:styled-content style=\"fixed-case\">EULAR<\/jats:styled-content> good response (26\u00b74 [23\u00b75\u201330\u00b79] vs. 26\u00b70 [22\u00b79\u201330\u00b76], <jats:italic>P<\/jats:italic> = 0\u00b796) and remission (26\u00b77 [21\u00b77\u201330\u00b73] vs. 26\u00b70 [23\u00b70\u201330\u00b71], <jats:italic>P<\/jats:italic> = 0\u00b783).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our real\u2010life study, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> did not affect the response to <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. If confirmed, these results suggest that obesity is not a limitation of <jats:styled-content style=\"fixed-case\">ABA<\/jats:styled-content> use in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12691","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:41:41Z","timestamp":1476409301000},"page":"1048-1052","source":"Crossref","is-referenced-by-count":28,"title":["Body mass index and response to abatacept in rheumatoid arthritis"],"prefix":"10.1111","volume":"46","author":[{"given":"Anais","family":"Gardette","sequence":"first","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Rhumatologie Assistance Publique \u2013 H\u00f4pitaux de Paris (APHP), H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Rhumatologie Assistance Publique \u2013 H\u00f4pitaux de Paris (APHP), H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Service de Rhumatologie DHU i2B and Inserm UMRS_938 APHP, H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Service de Rhumatologie DHU i2B and Inserm UMRS_938 APHP, H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Liot\u00e9","sequence":"additional","affiliation":[{"name":"UMR\u2010S 1132 Inserm Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Rhumatologie APHP, H\u00f4pital Lariboisi\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Fautrel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"Service de Rhumatologie APHP, H\u00f4pital La Piti\u00e9 Salp\u00e9tri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Rhumatologie Assistance Publique \u2013 H\u00f4pitaux de Paris (APHP), H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Meyer","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie F\u00e9d\u00e9ration de M\u00e9decine Translationnelle Centre de R\u00e9f\u00e9rence des Maladies Autoimmunes Rares H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"},{"name":"Service de Physiologie Exploration Fonctionnelle Musculaire F\u00e9d\u00e9ration de M\u00e9decine Translationnelle H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Sibilia","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie F\u00e9d\u00e9ration de M\u00e9decine Translationnelle Centre de R\u00e9f\u00e9rence des Maladies Autoimmunes Rares H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Dieud\u00e9","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"},{"name":"Service de Rhumatologie Assistance Publique \u2013 H\u00f4pitaux de Paris (APHP), H\u00f4pital Bichat Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.Obesity: preventing and managing the global epidemic. 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