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Hyperglycaemia seems to be the main factor in the pathogenesis of diabetic cardiomyopathy, often based on increased oxidative stress. Carvedilol, a \u03b2\u2010adrenergic blocker, has intrinsic antioxidant properties and was previously described to be effective in the protection of cardiac mitochondria against oxidative stress. The objective of this study was to evaluate the effect of carvedilol on hyperglycaemia\u2010induced oxidative damage and mitochondrial abnormalities in cardiac and skeletal muscle in streptozotocin\u2010treated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Body mass, blood glucose, the level of protein carbonylation, caspase\u20109\u2010 and caspase\u20103\u2010like activities, mitochondrial proteins, the status of antioxidant defence system and stress\u2010related proteins were evaluated in streptozotocin vs streptozotocin + carvedilol (1 mg\/kg\/day)\u2010treated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that carvedilol decreased blood glucose in streptozotocin\u2010treated animals. Content of catalase in the heart and<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>2,<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>1 and catalase in skeletal muscle were increased by carvedilol treatment in streptozotocin\u2010treated animals. At this particular time point, streptozotocin\u2010induced hyperglycaemia did not cause caspase activation or increase in protein carbonylation status. The data showed that carvedilol increased the level of antioxidant enzymes, what may contribute to preserve cell redox balance during hyperglycaemia. We also showed here for the first time that carvedilol effects on streptozotocin\u2010treated rats are tissue dependent, with a more predominant effect on skeletal muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on data showing modulation of the antioxidant network in the heart, carvedilol may be beneficial in diabetic patients without advanced disease complications, delaying their progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12696","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T11:24:16Z","timestamp":1479900256000},"page":"19-29","source":"Crossref","is-referenced-by-count":23,"title":["Carvedilol and antioxidant proteins in a type I diabetes animal model"],"prefix":"10.1111","volume":"47","author":[{"given":"C\u00e1tia V.","family":"Diogo","sequence":"first","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology Biocant Park University of Coimbra Cantanhede 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