{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:39:52Z","timestamp":1793727592635,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS 08\/0096"],"award-info":[{"award-number":["FIS 08\/0096"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS 08\/1424"],"award-info":[{"award-number":["FIS 08\/1424"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behaviour of three commercially available stents <jats:italic>in\u00a0vivo<\/jats:italic> (rabbits) and <jats:italic>in\u00a0vitro<\/jats:italic> (coculture of those stents with epithelial and fibroblast cell lines). Also, we investigated whether development of tracheal stenosis could be predicted by any biological marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The tracheae of 30 rabbits were implanted with either nitinol stents, with or without paclitaxel elution, or a cobalt\u2010based stent. An additional ten rabbits underwent mock implantation (controls). Serial peripheral venous blood samples were taken throughout the study, and several cytokines measured. Animals were euthanized on day 90, with immediate tracheal endoscopy and lavage performed, then necropsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rabbits with cobalt\u2010based stent exhibited more inflammation and the highest stenosis incidence, with reduced survival. Both <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro,<\/jats:italic> this stent induced higher <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 levels than nitinol stents. Most important, the presence of stent\u2010induced tracheal stenosis was closely associated to increase in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 expression in blood just 1\u00a0day after tracheal stent implantation: a 1\u00b719\u2010fold increase vs. baseline had 83% sensitivity, 83% specificity, 77% positive predictive value, 88% negative predictive value and 83% accuracy to predict development of stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cobalt\u2010based stent had the highest incidence of tracheal inflammation and stenosis. On the other hand, the paclitaxel\u2010eluting nitinol stent did not prevent those complications and provoked a marked reaction compared with the bare nitinol stent. Early increase in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 expression in blood after stent implantation could predict development of tracheal stenosis in rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12706","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T05:38:46Z","timestamp":1479793126000},"page":"84-92","source":"Crossref","is-referenced-by-count":21,"title":["Stent\u2010induced tracheal stenosis can be predicted by <scp>IL<\/scp>\u20108 expression in rabbits"],"prefix":"10.1111","volume":"47","author":[{"given":"Elena","family":"Arellano\u2010Orden","sequence":"first","affiliation":[{"name":"Unidad M\u00e9dico\u2010Quir\u00fargica de Enfermedades Respiratorias Instituto de Biomedicina de Sevilla (IBiS) Hospital Universitario Virgen del Roc\u00edo\/Universidad de Sevilla Seville 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