{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:54:35Z","timestamp":1772132075479,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathophysiology of acute pericarditis remains largely unknown, and biomarkers are needed to identify patients susceptible to complications. As adipose tissue has a pivotal role in cardiovascular disease pathogenesis, we hypothesized that quantification of epicardial fat volume (<jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content>) provides prognostic information in patients with acute pericarditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty (<jats:italic>n<\/jats:italic> = 50) patients with first diagnosis of acute pericarditis were enrolled in this study. Patients underwent a cardiac computerized tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scan to quantify <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> on a dedicated workstation. Patients were followed up in hospital for atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) development and up to 18 months for the composite clinical endpoint of development of constrictive, recurrent or incessant pericarditis or poor response to nonsteroidal anti\u2010inflammatory drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients presenting with chest pain had lower <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> vs. patients without chest pain (167\u00b72 \u00b1 21\u00b77 vs. 105\u00b71 \u00b1 11\u00b71 cm<jats:sup>3<\/jats:sup>, respectively, <jats:italic>P<\/jats:italic> &lt; 0\u00b701); <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> (but not body mass index) was strongly positively correlated with pericardial effusion size (<jats:italic>r<\/jats:italic> = 0\u00b7395, <jats:italic>P<\/jats:italic> = 0\u00b7007) and associated with in\u2010hospital <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. At follow\u2010up, patients that reached the composite clinical endpoint had lower <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). After adjustment for age, <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> was associated with lower odds ratio for the composite clinical endpoint point of poor response to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s or the development of constrictive, recurrent or incessant pericarditis during follow\u2010up (per 20 cm<jats:sup>3<\/jats:sup> increase in <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content> = 0\u00b7802 [0\u00b7656\u20130\u00b7981], <jats:italic>P<\/jats:italic> &lt; 0\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report for the first time a significant association of <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> with the clinical features and the outcome of patients with acute pericarditis. Measurement of <jats:styled-content style=\"fixed-case\">EFV<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> may have important prognostic implications in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12711","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T22:02:42Z","timestamp":1481234562000},"page":"129-136","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic implications of epicardial fat volume quantification in acute pericarditis"],"prefix":"10.1111","volume":"47","author":[{"given":"George","family":"Lazaros","sequence":"first","affiliation":[{"name":"1st Cardiology Department Hippokration Hospital Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-0143","authenticated-orcid":false,"given":"Alexios S.","family":"Antonopoulos","sequence":"additional","affiliation":[{"name":"1st 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