{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:14:52Z","timestamp":1790403292640,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymorphisms of the receptor for advanced glycation end products (<jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content>) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of this study was to investigate the possible role of two common <jats:italic><jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content><\/jats:italic> polymorphisms (\u2212429T&gt;C, \u2212374T&gt;A) in Hashimoto's thyroiditis; in parallel, we studied oxidative stress levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 300 consecutive euthyroid women were examined and classified into three groups: Hashimoto's thyroiditis with treatment (<jats:italic>n<\/jats:italic> = 96), Hashimoto's thyroiditis without treatment (<jats:italic>n<\/jats:italic> = 109) and controls (<jats:italic>n<\/jats:italic> = 95). For a rough evaluation of oxidative stress, total lipid peroxide levels in serum were measured. The \u2212429T&gt;C <jats:italic>Alu<\/jats:italic>I and \u2212374T&gt;A <jats:italic>Mfe<\/jats:italic>I polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content><\/jats:italic> were studied in genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant association of the <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content> system with Hashimoto's thyroiditis was found only with regard to the prevalence of the \u2212429T&gt;C, but not with \u2212374T&gt;A polymorphism. The levels of oxidative stress were significantly elevated in Hashimoto's thyroiditis patients under treatment. Further analysis demonstrated that an oxidative stress cut\u2010off value of 590 \u03bcmol\/L is associated with an increased risk of progression of Hashimoto's thyroiditis from euthyroidism to hypothyroidism; this risk is further increased in carriers of the <jats:italic><jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content><\/jats:italic> \u2212429T&gt;C polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that both examined risk factors may be implicated in the occurrence of Hashimoto's thyroiditis, but this covers only a fraction of the pathophysiology of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12739","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T23:42:44Z","timestamp":1487806964000},"page":"341-347","source":"Crossref","is-referenced-by-count":15,"title":["<i><scp>RAGE<\/scp><\/i> polymorphisms and oxidative stress levels in <scp>H<\/scp>ashimoto's 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