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Our group reported decreased risk for ET in carriers of the minor alleles of the rs2071746 and rs1051308 SNPs in the <jats:italic>haem\u2010oxygenases 1<\/jats:italic> and <jats:italic>2<\/jats:italic> (<jats:italic>HMOX1<\/jats:italic> and <jats:italic>HMOX2<\/jats:italic>)<jats:italic>,<\/jats:italic> respectively, involved in haem metabolism. We analysed whether <jats:italic>ALAD<\/jats:italic> rs1800435 alone and their interactions with the four common SNPs in the <jats:italic>HMOX1<\/jats:italic> and <jats:italic>HMOX2<\/jats:italic> genes are associated with the risk for ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We analysed the genotype and allele variants frequencies of <jats:italic>ALAD<\/jats:italic> rs1800435 in 202 patients with familial ET and 218 healthy controls using a TaqMan method. We also analysed the role of the interaction between <jats:italic>ALAD<\/jats:italic> rs1800435 and the <jats:italic>HMOX1<\/jats:italic> rs2071746, <jats:italic>HMOX1<\/jats:italic> rs2071747, <jats:italic>HMOX2<\/jats:italic> rs2270363 and <jats:italic>HMOX2<\/jats:italic> rs1051308 with the risk of developing ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of genotype and allelic variants of <jats:italic>ALAD<\/jats:italic> rs1800435 did not differ significantly between patients with ET and controls, and were not influenced by gender. Subjects carrying the <jats:italic>ALAD<\/jats:italic> rs1800435CC genotype (wild\u2010type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the ALAD rs1800435 SNP is not related with the risk for ET, but its interaction with the HMOX2 rs1051308 SNP could be weakly associated with the risk for this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12742","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T13:22:56Z","timestamp":1489065776000},"page":"348-356","source":"Crossref","is-referenced-by-count":6,"title":["Delta\u2010amino\u2010levulinic acid dehydratase gene and essential tremor"],"prefix":"10.1111","volume":"47","author":[{"given":"Jos\u00e9 A. 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