{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:43:54Z","timestamp":1780490634171,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Association between antiphospholipid syndrome in systemic lupus erythematosus (SLE<\/jats:styled-content>) and valvular heart disease (VHD<\/jats:styled-content>) is well reported, but relatively few studies have been carried out to establish the linkage between VHD<\/jats:styled-content> and SLE<\/jats:styled-content> itself. We aimed to investigate link between VHD<\/jats:styled-content> and SLE<\/jats:styled-content> and to evaluate the association of diverse factors with VHD<\/jats:styled-content> among these patients in a large\u2010scale population\u2010based study.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>We used the databases of the largest state\u2010mandated health service organization in Israel. All SLE<\/jats:styled-content> patients were included (n<\/jats:italic> = 5018) as well as their age and sex\u2010matched controls (n<\/jats:italic> = 25 090), creating a cross\u2010sectional population\u2010based study. Medical records of all subjects were analysed for documented VHD<\/jats:styled-content> and the presence of antiphospholipid antibodies (aPL<\/jats:styled-content>s). A logistic regression model was carried out to evaluate the diverse factors including SLE<\/jats:styled-content> and aPL<\/jats:styled-content>s as independent risk factors for VHD.<\/jats:p><\/jats:sec>Results<\/jats:title>Valvular heart disease were found to be more frequent among SLE<\/jats:styled-content> group when compared to controls (aortic stenosis, 1\u00b708% vs. 0\u00b735% respectively, P<\/jats:italic> < 0\u00b7001; aortic insufficiency, 1\u00b732% vs. 0\u00b729% respectively, P<\/jats:italic> < 0\u00b7001; mitral stenosis, 0\u00b774% vs. 0\u00b721% respectively, P<\/jats:italic> < 0\u00b7001; mitral insufficiency, 1\u00b791% vs. 0\u00b739% respectively, P<\/jats:italic> < 0\u00b7001). Male sex, hypertension, aPL<\/jats:styled-content>s and SLE<\/jats:styled-content> were found to be significant independent risk factors for VHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>All VHD<\/jats:styled-content> are more prevalent among SLE<\/jats:styled-content> patients when compared to controls. SLE<\/jats:styled-content> and aPL<\/jats:styled-content>s are independent risk factor for VHD<\/jats:styled-content> (OR<\/jats:styled-content> of 2\u00b746 and 1\u00b77, respectively). Physicians must be aware of such significant association, and routine echocardiography should be considered in SLE<\/jats:styled-content> patients regardless of their aPL<\/jats:styled-content> status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12744","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:42:16Z","timestamp":1489167736000},"page":"366-371","source":"Crossref","is-referenced-by-count":36,"title":["The association between systemic lupus erythematosus and valvular heart disease: an extensive data analysis"],"prefix":"10.1111","volume":"47","author":[{"given":"\u202c\u202c\u202c\u202cAbdulla","family":"Watad","sequence":"first","affiliation":[{"name":"Department of Medicine \u2018B\u2019 Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Zabludowicz Center for Autoimmune Diseases Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv 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