{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:17:01Z","timestamp":1783487821911,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The correct differentiation between unilateral and bilateral adrenal involvement in patients with primary aldosteronism (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) is of utmost importance to justify surgical treatment. The aim of this study was to determine the accuracy of adrenal imaging compared to adrenal venous sampling (<jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content>), histopathology and postoperative outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of all patients with unequivocal <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> who underwent unilateral laparoscopic adrenalectomy for primary aldosteronism between May 2004 and April 2015 were entered in this retrospective study. We compared computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) and magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) results with corresponding <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> data, histopathology findings and postoperative outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 175 patients underwent unilateral laparoscopic adrenalectomy for primary aldosteronism. <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> was successful in 152 patients and postoperative outcome available in 148 patients. Despite unilateral disease according to <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> results, bilateral normal glands were seen in 15 <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (17\u00b72%) and 7 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans (8\u00b75%), respectively. Unilateral enlargement of the nonhypersecreting adrenal gland was found in three <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (3\u00b75%) and 10 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans (12\u00b72%) of patients who showed aldosterone hypersecretion deriving from the contralateral gland. Fifteen <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (17\u00b72%) and 18 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans (22\u00b70%) revealed bilateral adrenal pathology despite unilateral aldosterone hypersecretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The accuracy of CT and magnetic resonance imaging in predicting unilateral disease is poor. AVS appears to be an essential diagnostic step to identify those patients who may benefit from unilateral adrenalectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12746","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T07:42:58Z","timestamp":1489650178000},"page":"372-377","source":"Crossref","is-referenced-by-count":64,"title":["Accuracy of adrenal imaging and adrenal venous sampling in diagnosing unilateral primary aldosteronism"],"prefix":"10.1111","volume":"47","author":[{"given":"Roland","family":"Ladurner","sequence":"first","affiliation":[{"name":"Chirurgische Klinik II Campus Innenstadt, Ludwig\u2010Maximilians Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sommerey","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik II Campus Innenstadt, Ludwig\u2010Maximilians Universit\u00e4t M\u00fcnchen Munich 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