{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:28:46Z","timestamp":1789766926338,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T00:00:00Z","timestamp":1499472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["22404"],"award-info":[{"award-number":["22404"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Protein\u2013energy wasting is a prevalent disorder in haemodialysis. Zinc\u2010\u03b12\u2010glycoprotein (ZAG<\/jats:styled-content>) and adipose triglyceride lipase (ATGL<\/jats:styled-content>) are novel adipokines with recognized lipolytic effects and proposed role in metabolic homoeostasis. This study was conducted to investigate the association of ZAG<\/jats:styled-content> and ATGL<\/jats:styled-content> concentrations with malnutrition\u2013inflammation score (MIS<\/jats:styled-content>) and metabolic profile of patients with haemodialysis.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Eighty\u2010eight patients under regular haemodialysis were divided based on MIS<\/jats:styled-content> to normal to mild wasting (NMW<\/jats:styled-content>; n<\/jats:italic>\u00a0=\u00a035) or moderate wasting (MW<\/jats:styled-content>; n<\/jats:italic>\u00a0=\u00a053) group. Anthropometric measurements along with fasting serum concentrations of ZAG<\/jats:styled-content>, ATGL<\/jats:styled-content>, free fatty acids (FFA<\/jats:styled-content>s), albumin, transferrin, total iron\u2010binding capacity (TIBC<\/jats:styled-content>), hs\u2010CRP<\/jats:styled-content>, lipid profile and glucose metabolism were assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>Adipose triglyceride lipase concentration was significantly higher in MW<\/jats:styled-content> than NMW<\/jats:styled-content> group (10\u00b789\u00a0\u00b1\u00a05\u00b77 vs. 8\u00b702\u00a0\u00b1\u00a03\u00b737 mIU<\/jats:styled-content>\/mL<\/jats:styled-content>; P<\/jats:italic>\u00a0=\u00a00\u00b7008). The ZAG<\/jats:styled-content> and FFA<\/jats:styled-content>s were not significantly different between two groups. ATGL<\/jats:styled-content> was directly correlated with FFA<\/jats:styled-content>s in all of the patients (r<\/jats:italic>\u00a0=\u00a00\u00b7284, P<\/jats:italic>\u00a0=\u00a00\u00b7007) and MW<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a00\u00b732, P<\/jats:italic>\u00a0=\u00a00\u00b7021), and marginally in NMW<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a00\u00b731, P<\/jats:italic>\u00a0=\u00a00\u00b7057) groups. ATGL<\/jats:styled-content> and odds of having mild or moderate wasting were significantly correlated (OR\u00a0=\u00a01\u00b721, P<\/jats:italic>\u00a0=\u00a00\u00b7033). A positive association was observed between ATGL<\/jats:styled-content> with TG<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a00\u00b731, P<\/jats:italic>\u00a0=\u00a00\u00b7049) and also with transferrin and TIBC<\/jats:styled-content> (r<\/jats:italic>\u00a0=\u00a00\u00b744, P<\/jats:italic>\u00a0=\u00a00\u00b7001) only in MW<\/jats:styled-content> group. An inverse relationship was observed between ATGL<\/jats:styled-content> and HDL<\/jats:styled-content> in all of the participants (r<\/jats:italic>=\u22120\u00b7222, P<\/jats:italic>\u00a0=\u00a00\u00b704). No significant correlation was observed between ZAG<\/jats:styled-content> and other parameters.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The serum concentrations of ATGL<\/jats:styled-content>, but not ZAG<\/jats:styled-content>, were significantly higher in MW<\/jats:styled-content> compared to NMW<\/jats:styled-content> group. Each unit increase in ATGL<\/jats:styled-content> concentrations was correlated with 21% increase in the odds of wasting severity. ATGL<\/jats:styled-content> might play a role in wasting pathogenesis and metabolic profile in haemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12774","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T13:32:45Z","timestamp":1497619965000},"page":"545-554","source":"Crossref","is-referenced-by-count":6,"title":["The relationship of serum adipokines with malnutrition inflammation score in haemodialysis"],"prefix":"10.1111","volume":"47","author":[{"given":"Elham","family":"Alipoor","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Esmaillzadeh","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran 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