{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:18:10Z","timestamp":1787897890628,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Emerging data suggest that heart\u2010related micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (miRs) may serve as circulating biomarkers of myocardial injury. We aimed to determine the circulating profile of miRs in patients with volume\u2010overloaded right ventricles after repair of tetralogy (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 104 <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> patients and 70 controls were recruited. The study was conducted in two phases: (1) determination of circulating heart\u2010related miRs described in left heart diseases (miR\u20101, miR\u2010133a, miR\u2010208a, miR\u2010208b and miR423\u20105p) by quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in 49 patients and 30 controls and followed by validation in an independent cohort of 55 patients and 40 controls; (2) expression profiling of serum samples from eight patients and eight controls, followed by validation. Alteration in circulating mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression was related to cardiac functional indices as assessed by 2D speckle tracking and 3D echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in serum levels of left heart\u2010associated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were found between patients and controls. Of the candidate 19 mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s identified by profiling, upregulation of miR\u201099b and down\u2010regulation of miR\u2010766 were validated. However, no correlations were found between miRs levels and echo indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In young adults with repaired <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> and volume\u2010overloaded right ventricles, circulating levels of miR\u201099b and miR\u2010766, but not left heart\u2010associated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, were significantly altered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12778","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T02:03:49Z","timestamp":1498788229000},"page":"574-582","source":"Crossref","is-referenced-by-count":12,"title":["Circulating Micro<scp>RNA<\/scp> in patients with repaired tetralogy of Fallot"],"prefix":"10.1111","volume":"47","author":[{"given":"Clare T. 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