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Sex\u2010specific differences of dipeptidyl peptidase\u2010four (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104) inhibitor effects on hepatic (<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>) and myocardial fat content (<jats:styled-content style=\"fixed-case\">MYCL<\/jats:styled-content>) have not yet been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty\u2010one T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients (20 male, 21 female) received a gliptin add\u2010on therapy if HbA1c goals were not reached under metformin monotherapy. They underwent cardiac and liver magnetic resonance tomography and spectroscopy before and 6\u00a0months after therapy initiation. Plasma samples were analysed for the growth differentiation factor 15 (<jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u201015), a novel marker for cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight patients on gliptin therapy completed the study. We observed a positive correlation between <jats:styled-content style=\"fixed-case\">MYCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> before therapy (<jats:italic>R<\/jats:italic>\u00a0=\u00a00\u00b741, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705). After 6\u00a0months of therapy, we noticed a significant weight reduction in women only (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) whereas waist circumference decreased similarly in both sexes. HbA1c sunk significantly in both sexes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002). <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> decreased significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70004), with women featuring higher basal <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). <jats:styled-content style=\"fixed-case\">MYCL<\/jats:styled-content> decreased in women only (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and <jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>\u201015 comparably in both sexes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>6\u00a0months of <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104\u2010therapy led to a significant overall decrease in <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> and body weight such as a reduction of <jats:styled-content style=\"fixed-case\">MYCL<\/jats:styled-content> only in women. This preliminary data set could implicate that gliptin may be a feasible therapy option in fatty liver patients with diabetes potentially including positive effects on cardiovascular function particularly in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12817","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:16:46Z","timestamp":1502957806000},"page":"829-838","source":"Crossref","is-referenced-by-count":14,"title":["Gliptin therapy reduces hepatic and myocardial fat in type 2 diabetic patients"],"prefix":"10.1111","volume":"47","author":[{"given":"Lana","family":"Kosi\u2010Trebotic","sequence":"first","affiliation":[{"name":"Gender Medicine Unit Division of Endocrinology and Metabolism Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Thomas","sequence":"additional","affiliation":[{"name":"Gender Medicine Unit Division of Endocrinology and Metabolism Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Harreiter","sequence":"additional","affiliation":[{"name":"Gender Medicine Unit Division of Endocrinology and Metabolism Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Chmelik","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnostics Centre of Excellence, High\u2010Field MR Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Trattnig","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnostics Centre of Excellence, High\u2010Field MR Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kautzky\u2010Willer","sequence":"additional","affiliation":[{"name":"Gender Medicine Unit Division of Endocrinology and Metabolism Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u00a0http:\/\/www.who.int\/diabetes\/en\/."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68967-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3260-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000254"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.9.2514"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.09.014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0413"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0190"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/635472"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.032"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp261"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-S007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.03.062"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1275"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.062"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12397"},{"key":"e_1_2_11_20_1","first-page":"783","article-title":"A general regression procedure for method transformation. 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