{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:10:27Z","timestamp":1769170227386,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Emerging data suggest impaired biventricular function in adults late after repair of ventricular septal defect (<jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>). We assessed and compared right (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) and left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) mechanics in adolescents and adults after surgical closure of doubly committed subarterial and perimembranous <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 subjects were studied: 29 patients after subarterial <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> repair (group I), 17 patients after perimembranous <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> repair (group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) and 29 age\u2010matched controls (group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mechanics were assessed using tissue Doppler and speckle\u2010tracking echocardiography, while <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> outflow systolic function was quantified by systolic excursion and fractional shortening (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, groups I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> had significantly reduced tricuspid annular systolic and diastolic velocities, isovolumic myocardial acceleration, <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> global longitudinal systolic and diastolic deformation parameters and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> outflow systolic excursion (all <jats:italic>P<\/jats:italic> &lt; .05). Group I, but not <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, had reduced <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> outflow <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = .008) and the lowest global <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal systolic strain (<jats:italic>P<\/jats:italic> = .008) and systolic strain rate (<jats:italic>P<\/jats:italic> = .014). In group I, postoperative aortic regurgitation was associated with lower <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> longitudinal systolic strain (<jats:italic>P<\/jats:italic> = .009) and early diastolic strain rate (<jats:italic>P<\/jats:italic> = .002), while right bundle branch block was associated with lower <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> systolic strain rate (<jats:italic>P<\/jats:italic> = .048). As a group, <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> outflow excursion (<jats:italic>P<\/jats:italic> &lt; .001) and <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = .001) were correlated with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> global systolic strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adolescents and adults late after repair of subarterial and perimembranous <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>s show impairment of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> systolic and diastolic myocardial deformation. The <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> outflow function and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic deformation appear to be worse after repair of subarterial defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12852","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T08:32:44Z","timestamp":1509352364000},"source":"Crossref","is-referenced-by-count":7,"title":["Ventricular mechanics after repair of subarterial and perimembranous <scp>VSD<\/scp>s"],"prefix":"10.1111","volume":"47","author":[{"given":"Sit\u2010yee","family":"Kwok","sequence":"first","affiliation":[{"name":"Division of Paediatric Cardiology Department of Paediatrics and Adolescent Medicine Queen Mary Hospital The University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna So\u2010shan","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of 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