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Paraoxonase\u20101 (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 with thyroid stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>), free T<jats:sub>4<\/jats:sub>, free T<jats:sub>3<\/jats:sub>, lipids and apolipoprotein (apo)A\u2010I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 activity (arylesterase activity), <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>, free T<jats:sub>4<\/jats:sub>, free T<jats:sub>3<\/jats:sub>, lipids and apoA\u2010I was measured in 2206 euthyroid subjects (aged 28\u201075\u00a0years; 1138 men (age 49\u00a0\u00b1\u00a013\u00a0years) and 1068 women (age 46\u00a0\u00b1\u00a012\u00a0years), recruited from the general population (<jats:styled-content style=\"fixed-case\">PREVEND<\/jats:styled-content> cohort).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In age\u2010 and sex\u2010adjusted analysis, <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 activity (divided into tertiles) was positively related to <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.045, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.036) and inversely to free T<jats:sub>4<\/jats:sub> (\u03b2\u00a0=\u00a0\u22120.042, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.050) but not to free T<jats:sub>3<\/jats:sub> (\u03b2\u00a0=\u00a0\u22120.027, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.20). PON\u20101 activity was positively related to total cholesterol, non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol and triglycerides, as well as to <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol and apoA\u2010I (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.01 to &lt;.001). The inverse relationship of <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 activity with free T<jats:sub>4<\/jats:sub> remained present after adjustment for lipids and other potential confounders (\u03b2\u00a0=\u00a0\u22120.066, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002), but the positive relationship with <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> lost significance (\u03b2\u00a0=\u00a00.034, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.11). The inverse relationship of <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 activity with free T<jats:sub>4<\/jats:sub> was not different in subjects with vs without MetS (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.94), nor modified by the presence of its individual components (<jats:italic>P\u00a0<\/jats:italic>\u2265<jats:italic>\u00a0<\/jats:italic>.22 for each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 activity is inversely associated with free T<jats:sub>4<\/jats:sub> in euthyroid subjects, suggesting that low\u2010normal thyroid function may affect <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>\u20101 regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12860","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T16:12:43Z","timestamp":1511539963000},"source":"Crossref","is-referenced-by-count":2,"title":["Serum paraoxonase\u20101 activity is inversely related to free thyroxine in euthyroid subjects: The <scp>PREVEND<\/scp> Cohort Study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-7244","authenticated-orcid":false,"given":"Lynnda J. 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