{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:55:19Z","timestamp":1790776519563,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["DDG.225\u201030.04.2015.DSC"],"award-info":[{"award-number":["DDG.225\u201030.04.2015.DSC"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) is a gluten\u2010sensitive autoimmune disorder. Gluten toxicity encompasses a wide spectrum of target organ functions and pathologies, including the activation of the immune response and triggering of oxidative stress. The aim of this study was to investigate inflammation and the redox balance in patients with active <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, and to evaluate whether alteration of mitochondrial function is involved in the disease status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In this prospective case\u2010control study, blood samples from sixteen adult <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients and sixteen healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) were investigated for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 plasma concentrations, for serum <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 arylesterase, total and Mn<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> antioxidant enzyme activities, induced <jats:styled-content style=\"fixed-case\">TBAR<\/jats:styled-content>s levels, and for lymphocyte mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients showed <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 concentrations significantly higher than <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> counterparts. Patients had a significantly higher content of induced <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> value, indicating a shift in their serum redox balance towards pro\u2010oxidant species. The assay of antioxidant enzyme activities showed a significant 25% increase in <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1, a higher total <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>, and a significant 21% higher Mn<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> in patients compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Lymphocyte mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> content in patients was significantly twofold higher than in <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, supporting the induction of mitochondrial biogenesis. The patients\u2019 mitochondrial compensatory response may explain the correlation between Mn<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> activity and mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> content. The patients\u2019 mitochondrial oxidative stress, cooperating to cytokines secretion, may justify the correlation between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 concentration and mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results highlight the mitochondrial involvement in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and suggest the evaluation of the mt<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> content as a potential diagnostic and follow\u2010up parameter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12877","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:57:16Z","timestamp":1513421836000},"source":"Crossref","is-referenced-by-count":14,"title":["Mitochondria and redox balance in coeliac disease: A case\u2010control study"],"prefix":"10.1111","volume":"48","author":[{"given":"Anna","family":"Picca","sequence":"first","affiliation":[{"name":"Department of Biosciences, Biotechnology and Biopharmaceutics University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Riezzo","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Pathophysiology National Institute of Digestive Diseases \u2013 I.R.C.C.S. \u201cSaverio de Bellis\u201d Castellana Grotte Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M. 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