{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:42:11Z","timestamp":1772109731006,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T00:00:00Z","timestamp":1518307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100386"],"award-info":[{"award-number":["81100386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400046"],"award-info":[{"award-number":["81400046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The therapeutic effects of bone marrow\u2010derived mononuclear cells (<jats:styled-content style=\"fixed-case\">BMMNC<\/jats:styled-content>s) transplantation in patients with nonischaemic dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>) are still under debate. Current randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) reported conflicting results. The aim of this study was to assess the effects of <jats:styled-content style=\"fixed-case\">BMMNC<\/jats:styled-content>s transplantation on left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) in patients with nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search of <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and Cochrane Controlled Trials Register was performed. We included <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s reporting data on <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> in patients with nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">BMMNC<\/jats:styled-content>s transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven RCTs including 463 patients were included. <jats:styled-content style=\"fixed-case\">BMMNC<\/jats:styled-content>s transplantation significantly improved <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> by 3.79% (95% CI: 0.56%\u20107.03%; <jats:italic>P<\/jats:italic> = .007) and <jats:styled-content style=\"fixed-case\">LVESV<\/jats:styled-content> by \u221224.36 mL (95% CI: \u221246.36 to \u22122.36 mL; <jats:italic>P<\/jats:italic> = .03), while had no impact on the risk of all\u2010cause death (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.92; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.41 to 2.08%; <jats:italic>P<\/jats:italic> = .84). Subgroup analysis demonstrated a more significant improvement of <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> in patients with longer follow\u2010up (~15 months to 5 years) than shorter ones (12 months). Moreover, using bone marrow mononuclear cells was more effective than using G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\u2010stimulated bone marrow\/peripheral blood stem cells in the improvement of <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> in patients with nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bone marrow\u2010derived mononuclear cells transplantation is associated with a moderate, but significant, improvement in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> in patients with nonischaemic <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>. This meta\u2010analysis supports further <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> conductions using <jats:styled-content style=\"fixed-case\">BMMNC<\/jats:styled-content>s transplantation with larger patient's population and longer term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12894","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T06:52:43Z","timestamp":1516690363000},"source":"Crossref","is-referenced-by-count":13,"title":["Bone marrow\u2010derived mononuclear cell therapy for nonischaemic dilated cardiomyopathy\u2014A meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-8933","authenticated-orcid":false,"given":"Yanting","family":"Wen","sequence":"first","affiliation":[{"name":"Center of Translational Medicine Jiangsu Key Laboratory of Molecular Medicine Nanjing University Medical School Nanjing 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