{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:58:36Z","timestamp":1771016316121,"version":"3.50.1"},"reference-count":251,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The genetic risk of autoimmune hepatitis is insufficient to explain the observed risk, and epigenetic changes may explain disparities in disease occurrence in different populations within and between countries. The goal of this review was to examine how epigenetic changes induced by the environment or inherited as a phenotypic trait may affect autoimmune hepatitis and be amenable to therapeutic intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Pertinent abstracts were identified in PubMed by multiple search terms. The number of abstracts reviewed was 1689, and the number of full\u2010length articles reviewed exceeded 150.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Activation of pro\u2010inflammatory genes in autoimmune disease is associated with hypomethylation of deoxyribonucleic acid and modification of histones within chromatin. Organ\u2010specific microribonucleic acids can silence genes by marking messenger ribonucleic acids for degradation, and they can promote inflammatory activity or immunosuppression. High circulating levels of the microribonucleic acids 21 and 122 have been demonstrated in autoimmune hepatitis, and they may increase production of pro\u2010inflammatory cytokines. Microribonucleic acids are also essential for maintaining regulatory T cells. Drugs, pollutants, infections, diet and ageing can induce inheritable epigenetic changes favouring autoimmunity. Reversal is feasible by manipulating enzymes, transcription factors, gene\u2010silencing molecules and toxic exposures or by administering methyl donors and correcting vitamin D deficiency. Gene targets, site specificity, efficacy and consequences are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Potentially reversible epigenetic changes may affect the occurrence and outcome of autoimmune hepatitis, and investigations are warranted to determine the nature of these changes, key genomic targets, and feasible interventions and their consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12899","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:14:20Z","timestamp":1517404460000},"source":"Crossref","is-referenced-by-count":30,"title":["Epigenetic changes and their implications in autoimmune hepatitis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3065","authenticated-orcid":false,"given":"Albert J.","family":"Czaja","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine and Science Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.048"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3708-7"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130415"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178696"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.82"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120609"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90041-V"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.019"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0333-2"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02918.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80347-4"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.08.019"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.11.005"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300611"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.034"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01229.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.020"},{"key":"e_1_2_4_20_1","first-page":"2197","article-title":"Genetic distinctions between types 1 and 2 autoimmune hepatitis","volume":"92","author":"Czaja AJ","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.13.21"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4675-y"},{"key":"e_1_2_4_23_1","first-page":"5153","article-title":"Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis","volume":"8","author":"Lin R","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i42.9257"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.04.022"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5199"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005670111068"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1733-4"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2017.74"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21518"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071382"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.08.016"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27131"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.994507"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.047"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-015-0098-9"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313499419"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-015-0014-y"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2487"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740902758875"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34376"},{"key":"e_1_2_4_42_1","first-page":"535","article-title":"Environmental triggers and epigenetic deregulation in autoimmune disease","volume":"12","author":"Javierre BM","year":"2011","journal-title":"Discov Med"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1086996"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0144"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136908"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05913"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/38444"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2009.10.009"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.5.612"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100340697"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05767.x"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.006"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00616-X"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.04.031"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.07.002"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1685"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052610-091920"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6538"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359901112"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00564-6"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt035"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.12.008"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.011"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00428"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416022-4.00002-0"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.013"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.4137\/GEG.S12144"},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8172-8"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.12.027"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0107064"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7920"},{"key":"e_1_2_4_75_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.24977"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170116"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210597"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.16.17093"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12750"},{"key":"e_1_2_4_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.100289.109"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364123"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000160"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_006"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.2741\/1802"},{"key":"e_1_2_4_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.78"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5187"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.81"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021321"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb05964.x"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90051-Q"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-454-4_7"},{"key":"e_1_2_4_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1652"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.159"},{"key":"e_1_2_4_94_1","first-page":"804","article-title":"Abnormal histone modification patterns in lupus CD4+ T cells","volume":"35","author":"Hu N","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_4_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521"},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.027"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900012200"},{"key":"e_1_2_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_4_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139857"},{"key":"e_1_2_4_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.282"},{"key":"e_1_2_4_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513499093"},{"key":"e_1_2_4_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.065"},{"key":"e_1_2_4_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12776"},{"key":"e_1_2_4_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22569"},{"key":"e_1_2_4_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-170589"},{"key":"e_1_2_4_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.05.005"},{"key":"e_1_2_4_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21639"},{"key":"e_1_2_4_109_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_4_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03032.x"},{"key":"e_1_2_4_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24691"},{"key":"e_1_2_4_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-153"},{"key":"e_1_2_4_113_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050480"},{"key":"e_1_2_4_114_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803162"},{"key":"e_1_2_4_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-014-9547-z"},{"key":"e_1_2_4_116_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.1.2.1066"},{"key":"e_1_2_4_117_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.002"},{"key":"e_1_2_4_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.005"},{"key":"e_1_2_4_119_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.18827"},{"key":"e_1_2_4_120_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63966"},{"key":"e_1_2_4_121_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.107"},{"key":"e_1_2_4_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24766"},{"key":"e_1_2_4_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02213.x"},{"key":"e_1_2_4_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.050"},{"key":"e_1_2_4_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01624.x"},{"key":"e_1_2_4_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.030"},{"key":"e_1_2_4_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29116"},{"key":"e_1_2_4_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1027"},{"key":"e_1_2_4_129_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i45.6546"},{"key":"e_1_2_4_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02650.x"},{"key":"e_1_2_4_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089565"},{"key":"e_1_2_4_132_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.8.4486"},{"key":"e_1_2_4_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr114"},{"key":"e_1_2_4_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.7.4402"},{"key":"e_1_2_4_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.010"},{"key":"e_1_2_4_136_1","first-page":"w14191","article-title":"Epigenetics of T lymphocytes in health and disease","volume":"145","author":"Leoni C","year":"2015","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_4_137_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2017.1284821"},{"key":"e_1_2_4_138_1","first-page":"285","article-title":"Murine models of lupus induced by hypomethylated T cells","volume":"102","author":"Richardson B","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_4_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301395"},{"key":"e_1_2_4_140_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4083"},{"key":"e_1_2_4_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900034"},{"key":"e_1_2_4_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2487"},{"key":"e_1_2_4_143_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-219584"},{"key":"e_1_2_4_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838105"},{"key":"e_1_2_4_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.09.001"},{"key":"e_1_2_4_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.12.003"},{"key":"e_1_2_4_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0376-6"},{"key":"e_1_2_4_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00360"},{"key":"e_1_2_4_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22983"},{"key":"e_1_2_4_150_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005370"},{"key":"e_1_2_4_151_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001620"},{"key":"e_1_2_4_152_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00435.2010"},{"key":"e_1_2_4_153_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67390"},{"key":"e_1_2_4_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301755q"},{"key":"e_1_2_4_155_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.154187.112"},{"key":"e_1_2_4_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500398102"},{"key":"e_1_2_4_157_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.096826.109"},{"key":"e_1_2_4_158_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69735"},{"key":"e_1_2_4_159_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0143"},{"key":"e_1_2_4_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24164"},{"key":"e_1_2_4_161_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157529.113"},{"key":"e_1_2_4_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(86)90304-6"},{"key":"e_1_2_4_163_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.7.2197"},{"key":"e_1_2_4_164_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116576"},{"key":"e_1_2_4_165_1","first-page":"530","article-title":"Procainamide inhibits DNA methyltransferase in a human T cell line","volume":"18","author":"Scheinbart LS","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_4_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10833"},{"key":"e_1_2_4_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205699"},{"key":"e_1_2_4_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"e_1_2_4_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21423"},{"key":"e_1_2_4_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.031"},{"key":"e_1_2_4_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20049"},{"key":"e_1_2_4_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306069344"},{"key":"e_1_2_4_173_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1097OC"},{"key":"e_1_2_4_174_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11898"},{"key":"e_1_2_4_175_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.7.16250"},{"key":"e_1_2_4_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-011-9113-3"},{"key":"e_1_2_4_177_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-7-1687"},{"key":"e_1_2_4_178_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600468200"},{"key":"e_1_2_4_179_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802024772"},{"key":"e_1_2_4_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.01.042"},{"key":"e_1_2_4_181_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8700"},{"key":"e_1_2_4_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.100"},{"key":"e_1_2_4_183_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028282"},{"key":"e_1_2_4_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.021"},{"key":"e_1_2_4_185_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603324"},{"key":"e_1_2_4_186_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12825"},{"key":"e_1_2_4_187_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.06.043"},{"key":"e_1_2_4_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.86"},{"key":"e_1_2_4_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.69"},{"key":"e_1_2_4_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800287"},{"key":"e_1_2_4_191_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.22191"},{"key":"e_1_2_4_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f49a"},{"key":"e_1_2_4_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.07.004"},{"key":"e_1_2_4_194_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-170365"},{"key":"e_1_2_4_195_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707224200"},{"key":"e_1_2_4_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.12.013"},{"key":"e_1_2_4_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.01.008"},{"key":"e_1_2_4_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01464758"},{"key":"e_1_2_4_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.015"},{"key":"e_1_2_4_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1069-9"},{"key":"e_1_2_4_201_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9194-2"},{"key":"e_1_2_4_202_1","first-page":"407","article-title":"The role of vitamin D in autoimmune hepatitis","volume":"5","author":"Luong KV","year":"2013","journal-title":"J Clin Med Res"},{"key":"e_1_2_4_203_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3267-3"},{"key":"e_1_2_4_204_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S"},{"key":"e_1_2_4_205_1","doi-asserted-by":"publisher","DOI":"10.2741\/1455"},{"key":"e_1_2_4_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041390218"},{"key":"e_1_2_4_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.01.001"},{"key":"e_1_2_4_208_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101211"},{"key":"e_1_2_4_209_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803217"},{"key":"e_1_2_4_210_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.127209"},{"key":"e_1_2_4_211_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq124"},{"key":"e_1_2_4_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.028"},{"key":"e_1_2_4_213_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.234666"},{"key":"e_1_2_4_214_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0241"},{"key":"e_1_2_4_215_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12122"},{"key":"e_1_2_4_216_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107920.110"},{"key":"e_1_2_4_217_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041112"},{"key":"e_1_2_4_218_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102412"},{"key":"e_1_2_4_219_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6408"},{"key":"e_1_2_4_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1084-8"},{"key":"e_1_2_4_221_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i31.4249"},{"key":"e_1_2_4_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835"},{"key":"e_1_2_4_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.035"},{"key":"e_1_2_4_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.053"},{"key":"e_1_2_4_225_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317023110"},{"key":"e_1_2_4_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2540"},{"key":"e_1_2_4_227_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29148"},{"key":"e_1_2_4_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31715-9"},{"key":"e_1_2_4_229_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800910791517217"},{"key":"e_1_2_4_230_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-3-5"},{"key":"e_1_2_4_231_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.062706.153223"},{"key":"e_1_2_4_232_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh045"},{"key":"e_1_2_4_233_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212264109"},{"key":"e_1_2_4_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03309-9"},{"key":"e_1_2_4_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.016"},{"key":"e_1_2_4_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.10.015"},{"key":"e_1_2_4_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.046"},{"key":"e_1_2_4_238_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130376"},{"key":"e_1_2_4_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09589"},{"key":"e_1_2_4_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065173"},{"key":"e_1_2_4_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04431"},{"key":"e_1_2_4_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25204"},{"key":"e_1_2_4_243_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-192"},{"key":"e_1_2_4_244_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-320093"},{"key":"e_1_2_4_245_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3092751"},{"key":"e_1_2_4_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00120"},{"key":"e_1_2_4_247_1","first-page":"72","article-title":"Epigenetics in 2013. DNA methylation and miRNA: key roles in systemic autoimmunity","volume":"2014","author":"Richardson BC","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_4_248_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543770902895727"},{"key":"e_1_2_4_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.04.001"},{"key":"e_1_2_4_250_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211813200"},{"key":"e_1_2_4_251_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00132.2013"},{"key":"e_1_2_4_252_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14324"}],"updated-by":[{"DOI":"10.1111\/eci.13793","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000}}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:25:02Z","timestamp":1695554702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,18]]},"references-count":251,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/eci.12899"],"URL":"https:\/\/doi.org\/10.1111\/eci.12899","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/eci.13793","asserted-by":"object"}]},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,18]]},"article-number":"e12899"}}