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Around\u2010the\u2010clock ambulatory blood pressure monitoring (ABPM), however, reveals BP undergoes 24\u2010hours patterning characterized in normotensives and uncomplicated hypertensives by striking morning\u2010time rise, 2\u00a0daytime peaks\u2014one ~2\u20103\u00a0hours after awakening and the other early evening, small midafternoon nadir and 10\u201020% decline (BP dipping) in the asleep BP mean relative to the wake\u2010time BP mean. A growing number of outcome trials substantiate correlation between BP and target organ damage, vascular and other risks is greater for the ABPM\u2010derived asleep BP mean, independent and stronger predictor of CVD risk, than daytime OBPM or ABPM\u2010derived awake BP. Additionally, bedtime hypertension chronotherapy, that is, ingestion of \u22651 conventional hypertension medications at bedtime to achieve efficient attenuation of asleep BP, better reduces total CVD events by 61% and major events (CVD death, myocardial infarction, ischaemic and haemorrhagic stroke) by 67%\u2014even in more vulnerable chronic kidney disease, diabetes and resistant hypertension patients\u2014than customary on\u2010awaking therapy that targets wake\u2010time BP. Such findings of around\u2010the\u2010clock ABPM and bedtime hypertension outcome trials, consistently indicating greater importance of asleep BP than daytime OBPM or ambulatory awake BP, call for a new definition of true arterial hypertension plus modern approaches for its diagnosis and management.<\/jats:p>","DOI":"10.1111\/eci.12909","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T02:35:15Z","timestamp":1518143715000},"source":"Crossref","is-referenced-by-count":54,"title":["Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-5901","authenticated-orcid":false,"given":"Ram\u00f3n C.","family":"Hermida","sequence":"first","affiliation":[{"name":"Bioengineering &amp; Chronobiology Laboratories Atlantic Research Center for Information and Communication Technologies 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