{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:57:26Z","timestamp":1762955846851,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,11]],"date-time":"2018-03-11T00:00:00Z","timestamp":1520726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0042\/0068","RD12\/0042\/0010","RD12\/0042\/0069","PI13\/00513","RD12\/0042\/0063"],"award-info":[{"award-number":["RD12\/0042\/0068","RD12\/0042\/0010","RD12\/0042\/0069","PI13\/00513","RD12\/0042\/0063"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Anticoagulation control in patients with atrial fibrillation (AF<\/jats:styled-content>) has a multidisciplinary approach although is usually managed by general practitioners (GP<\/jats:styled-content>) or haematologists. The aim of our study was to assess the quality of anticoagulation control with vitamin K antagonists (VKA<\/jats:styled-content>s) in relation to the responsible specialist in a \u201creal\u2010world\u201d AF<\/jats:styled-content> population.<\/jats:p><\/jats:sec>Methods<\/jats:title>We consecutively enrolled VKA<\/jats:styled-content> anticoagulated patients included in the FANTASIIA<\/jats:styled-content> Registry from 2013 to 2015. We analysed demographical, clinical characteristics and the quality of anticoagulation control according to the specialist responsible (ie GP<\/jats:styled-content>s or haematologists).<\/jats:p><\/jats:sec>Results<\/jats:title>Data on 1584 patients were included (42.5% females, mean age 74.0\u00a0\u00b1\u00a09.4\u00a0years): 977 (61.7%) patients were controlled by GP<\/jats:styled-content>s and 607 (38.3%) by haematologists. Patients managed by GP<\/jats:styled-content>s had higher previous heart disease (53.2% vs 43.3%, P<\/jats:italic>\u00a0<\u00a0.001), heart failure (32.9% vs 26.5%, P<\/jats:italic>\u00a0<\u00a0.008) and dilated cardiomyopathy (15.2% vs 8.7%, P<\/jats:italic>\u00a0<\u00a0.001) with better renal function (69.3\u00a0\u00b1\u00a024.7 vs 63.1\u00a0\u00b1\u00a021.4\u00a0mL\/min, P<\/jats:italic>\u00a0<\u00a0.001) compared to patients managed by haematologists. There was no difference between groups in the type of AF<\/jats:styled-content>, CHA<\/jats:styled-content>2<\/jats:sub>DS<\/jats:styled-content>2<\/jats:sub>\u2010VAS<\/jats:styled-content>c or HAS<\/jats:styled-content>\u2010BLED<\/jats:styled-content> scores, but patients with electrical cardioversion were more prevalent in GP<\/jats:styled-content> group. The overall mean time in therapeutic range (TTR<\/jats:styled-content>) assessed by Rosendaal method was 61.5\u00a0\u00b1\u00a024.9%; 52.6% of patients had TTR<\/jats:styled-content><65% and 60% of patients had TTR<\/jats:styled-content><70%. TTR<\/jats:styled-content> was significantly lower in patients controlled by haematologists than by GP<\/jats:styled-content>s (63\u00a0\u00b1\u00a024.4 vs 59.2\u00a0\u00b1\u00a025.6, P<\/jats:italic>\u00a0<\u00a0.005).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>About 60% of AF<\/jats:styled-content> patients anticoagulated with VKA<\/jats:styled-content>s had poor anticoagulation control (ie TTR<\/jats:styled-content><70%), and their management was only slightly better than when it is managed by general practitioners.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12910","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T07:29:07Z","timestamp":1518161347000},"source":"Crossref","is-referenced-by-count":5,"title":["Relation of quality of anticoagulation control with different management systems among patients with atrial fibrillation: Data from FANTASIIA<\/scp> Registry"],"prefix":"10.1111","volume":"48","author":[{"given":"Inmaculada","family":"Rold\u00e1n Rabad\u00e1n","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Universitario La Paz Instituto de Investigaci\u00f3n de La Paz (IDIPAZ) CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Asunci\u00f3n","family":"Esteve\u2010Pastor","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca) CIBER\u2010CV Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Anguita\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias de la Salud Instituto de Investigaci\u00f3n Biomedica de A Coru\u00f1a (INIBIC) Universidade da Coru\u00f1a CIBER\u2010CV A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Camacho Siles","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario La Paz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Angustias","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario La Paz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Ruiz Ortiz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca) CIBER\u2010CV Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Mart\u00ednez Sell\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario Gregorio Mara\u00f1\u00f3n Complutense University European University of Madrid CIBER\u2010CV Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Bertomeu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de San Juan CIBER\u2010CV Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory 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