{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:46:42Z","timestamp":1784544402848,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) is a neurotrophin that has a protective role in the nervous system and is involved in neural plasticity. It is abundant in the central nervous system, but is also expressed in the gastrointestinal tract. Coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), characterised by intestinal inflammation, has some comorbidity with neurologic and mental disorders. The aim of this study was to evaluate circulating <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> concentrations in patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> at diagnosis or on a gluten\u2010free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>) for longer than 1 year and in healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty newly diagnosed patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (aged 8.6 \u00b1 3.7 years, 64.0% females), thirty\u2010nine patients on <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> for longer than 1 year (aged 10.4 \u00b1 3.4 years, 71.8% females) and 36 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (aged 8 \u00b1 1.7 years, 33.3% females) were included in the study. Along with anthropometric evaluation and standard blood chemistry, serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels were measured by a specific immunoenzymatic assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients at diagnosis and on <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> had significantly higher <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels (26 110 \u00b1 8204 and 28 860 \u00b1 7992 pg\/mL), respectively, than <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (19 630 \u00b1 8093 pg\/mL, <jats:italic>P<\/jats:italic> &lt; .001 for both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> groups). Patients on <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> had significantly higher <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels than those at diagnosis (<jats:italic>P<\/jats:italic> = .02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> concentrations were higher in patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, regardless of their status of gluten consumption. This could be attributed either to a potential protective response to the inflammation of the intestine or to chronic stress.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12916","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T12:21:00Z","timestamp":1519302060000},"source":"Crossref","is-referenced-by-count":4,"title":["Serum brain\u2010derived neurotrophic factor in children with coeliac disease"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-7852","authenticated-orcid":false,"given":"Daphne","family":"Margoni","sequence":"first","affiliation":[{"name":"First Department of Pediatrics National and Kapodistrian University of Athens Medical School \u201cAghia Sophia\u201d Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Michalakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry \u201cAghia Sophia\u201d 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