{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:28:38Z","timestamp":1791822518380,"version":"4.3.4"},"reference-count":102,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular inflammation underlies most forms of cardiovascular disease, which remains a prevalent cause of death among the global population. Advances in the biology of neutrophils, as well as insights into their dynamics in tissues, have revealed that these cells are prominent drivers of vascular inflammation though derailed activation within blood vessels. The development of powerful imaging techniques, as well as identification of cells and molecules that regulate their activation within vessels, including platelets and catecholamines, has been instrumental to better understand the mechanisms through which neutrophils protect or damage the organism. Other advances in our understanding of how these leucocytes exert detrimental functions on neighbouring cells, including the formation of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010based extracellular traps, constitute milestones in defining neutrophil\u2010driven inflammation. Here, we review emerging mechanisms that regulate intravascular activation and effector functions of neutrophils, and discuss specific pathologies in which these processes are relevant. We argue that identification of pathways and mechanisms specifically engaged within the vasculature may provide effective therapies to treat this prevalent group of pathologies.<\/jats:p>","DOI":"10.1111\/eci.12940","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T07:02:19Z","timestamp":1524466939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Neutrophils as effectors of vascular inflammation"],"prefix":"10.1111","volume":"48","author":[{"given":"Diego","family":"G\u00f3mez\u2010Moreno","sequence":"first","affiliation":[{"name":"Area of Developmental and Cell Biology Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-5477","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Adrover","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-555X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Area of Developmental and Cell Biology Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Madrid Spain"},{"name":"Institute for Cardiovascular Prevention (IPEK) Ludwig\u2010Maximilians University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.Cardiovascular diseases (CVDs);2017.http:\/\/www.who.int\/mediacentre\/factsheets\/fs317\/en\/. Accessed December 15 2017."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.257535"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-618538"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2514"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-164023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.10.2154.2154"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-259028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108517"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-310532"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.03.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8292-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.25"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2062"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-343566"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1939"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.11.3550"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060925"},{"key":"e_1_2_8_22_1","first-page":"1353","volume-title":"Platelets","author":"Michelson AD","year":"2013"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9060143"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300512"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00653"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1265924"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01553.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.06.001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256478"},{"key":"e_1_2_8_31_1","first-page":"3450","article-title":"Platelet depletion and aspirin treatment protect mice in a two\u2010event model of transfusion\u2010related acute lung injury","volume":"119","author":"Looney MR","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29499"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-624023"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13464"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.021"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06185"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004414"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00822.2004"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11260"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022304"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-725754"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14780"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-660746"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.10.151"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12447"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.4.895"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.013"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.09.013"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15367"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2987"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00269"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.044"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3887"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13239"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3829"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032366"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7673"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00256"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8897"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.011"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-437772"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.242859"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0405193"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12710"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-08-0662"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301059110"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-405993"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303479"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303312"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301627"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-11-0720"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.159"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1841"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.659029"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72305"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.032"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.133.4.885"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.024"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-02-0162"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170689"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304944"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-514992"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.534503"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24993"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002470"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00770-7"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309692"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.961714"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm810"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8064"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000156877.94472.a5"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450115666141110093013"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89761"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.362"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-529982"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-260513"},{"key":"e_1_2_8_101_1","volume-title":"Deep Venous Thrombosis (DVT), Lower Extremity","author":"Schick MA","year":"2017"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112322"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13907"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:42:27Z","timestamp":1694522547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,13]]},"references-count":102,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/eci.12940"],"URL":"https:\/\/doi.org\/10.1111\/eci.12940","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,13]]},"assertion":[{"value":"2018-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12940"}}